146555-81-9

Basic information

• Product Name: 7-{[2-(4-hydroxyphenyl)ethyl]amino}-4,5-dihydropyrrolo[4,3,2-de]quinolin-8(3H)-one
• CAS NO: 146555-81-9
• Molecular Formula: C₁₈H₁₇N₃O₂
• Molecular Weight: 307.3465
• Mol File: 146555-81-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 597.7°C at 760 mmHg
• Flash Point: 315.3°C
• Density: 1.41g/cm³
• Vapor Pressure: 7.02E-15mmHg at 25°C
• Refractive Index: 1.725
• CAS DataBase Reference: 7-{[2-(4-hydroxyphenyl)ethyl]amino}-4,5-dihydropyrrolo[4,3,2-de]quinolin-8(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-{[2-(4-hydroxyphenyl)ethyl]amino}-4,5-dihydropyrrolo[4,3,2-de]quinolin-8(3H)-one(146555-81-9)
• EPA Substance Registry System: 7-{[2-(4-hydroxyphenyl)ethyl]amino}-4,5-dihydropyrrolo[4,3,2-de]quinolin-8(3H)-one(146555-81-9)

Safety Data

• Hazardous Substances Data: 146555-81-9(Hazardous Substances Data)

Upstream product

• 51-67-2 tyrosamine 
• 60-19-5 tyramine hydrochloride 
• 160208-44-6 7-Methoxy-2,4-dihydropyrrolo<4,3,2-de>quinolin-8(1H)-one 
• 1393471-50-5 C₁₄H₁₉IN₂O 
• 144085-18-7 1-allyl-4-iodo-3-(iodomethyl)-6-methoxyindoline 
• 1408314-69-1 ethyl 7-methoxy-4,5-dihydropyrrolo[4,3,2-de]quinoline-1(3H)-carboxylate 
• 1408314-68-0 5-tert-butyl 1-ethyl 7-methoxy-3,4-dihydropyrrolo[4,3,2-de]quinoline-1,5-dicarboxylate 
• 1393471-42-5 5-tert-butyl 1-ethyl 7-methoxy-2,2a,3,4-tetrahydropyrrolo[4,3,2-de]quinoline-1,5-dicarboxylate 
• 1393471-41-4 ethyl 3-(2-(tert-butoxycarbonylamino)ethyl)-4-iodo-6-methoxyindoline-1-carboxylate 
• 1393471-40-3 tert-butyl 2-(1-allyl-4-iodo-6-methoxyindolin-3-yl)ethylcarbamate 
• 1393471-49-2 2-(1-allyl-4-iodo-6-methoxyindolin-3-yl)acetonitrile 
• 157669-64-2 pyrrolo<4,3,2-de>-quinoline-7,8-dione 
• 175792-34-4 8-chloro-6,7-dimethoxy-4-(dimethoxymethyl)-5-nitroquinoline 
• 184957-93-5 5-amino-8-chloro-1,2,3,4-tetrahydro-6,7-dimethoxy-4-(dimethoxymethyl)quinoline 

Relevant articles and documents

Synthesis and antiproliferative evaluation of 7-aminosubstituted pyrroloiminoquinone derivatives

Coupling of five amines on the 7-methoxy-1,3,4,5-tetrahydropyrrolo[4,3,2-de]quinoline core was achieved and afforded, in particular, an opened analogue of the natural alkaloid wakayin. Evaluation of cytotoxic activity of compounds 2, 10-13 on L1210 cells afforded IC50 in the range 0.25-5.3 μM. (C) 2000 Elsevier Science Ltd.

Synthesis of tetrahydropyrroloiminoquinone alkaloids based on electrochemically generated hypervalent iodine oxidative cyclization

[Chemical equation presented] An approach to the synthesis of the tetrahydropyrroloiminoquinone alkaloids has been developed and applied to the preparation of N-1-βD-ribofuranosyltetrahydropyrroloiminoquinones. The strategy utilizes oxidative cyclization

A biomimetic approach to the discorhabdin alkaloids: Total syntheses of discorhabdins C and E and dethiadiscorhabdin D

The characteristic spirodienone structure of the discorhabdin alkaloids is readily formed by reaction of the tyramine-substituted indoloquinonimines 26, 35, and 36 with cupric chloride, triethylamine, and oxygen. This cyclization provides a possibly biomimetic route to discorhabdins C and E (41 and 42). The unbrominated spirodienone 40 reacts with hydrogen over Pd/C to give enone 46. Bromination at the α position gives a mixture of bromoenones that undergo smooth conversion to dethiadiscorhabdin D (4) upon treatment with basic alumina.