146557-72-4Relevant academic research and scientific papers
3′-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Vanheusden, Veerle,Munier-Lehmann, Hélène,Froeyen, Matheus,Dugué, Laurence,Heyerick, Arne,De Keukeleire, Denis,Pochet, Sylvie,Busson, Roger,Herdewijn, Piet,Van Calenbergh, Serge
, p. 3811 - 3821 (2003)
Thymidine monophosphate kinase (TMPK) of Mycobacterium tuberculosis (TMPKmt) represents an attractive target for blocking the bacterial DNA synthesis. In an attempt to find high-affinity inhibitors of TMPKmt, a cavity in the enzyme at the 3′-position was
3'-C-branched thymidine 5'-triphosphates: Synthesis, application, and coupling with near-infrared oxazine fluorescent dye
Schoetzau, Thomas,Koert, Ulrich,Engels, Joachim W.
, p. 707 - 713 (2007/10/03)
The synthesis of the novel class of 3'-C-modified thymidine nucleotides is described. The aldehyde 1 was converted into the derivatives 5, 7, and 10 that differ in the length of the carbon chain. One-pot phosphorylation gave the corresponding triphosphate
