146566-05-4

Basic information

• Product Name: 1-(4-methylphenyl)ethane-1,2-diol
• Synonyms: (4-Methylphenyl)-1,2-ethanediol; 1-(4-Methylphenyl)-1,2-ethanediol; 1,2-Ethanediol, 1-(4-methylphenyl)-; 1,2-Ethanediol, 1-p-tolyl-
• CAS NO: 146566-05-4
• Molecular Formula: C₉H₁₂O₂
• Molecular Weight: 152.1904
• Mol File: 146566-05-4.mol
• Article Data: 74

Chemical Properties

• Boiling Point: 309.1°C at 760 mmHg
• Flash Point: 152.9°C
• Density: 1.133g/cm³
• Vapor Pressure: 0.000282mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 1-(4-methylphenyl)ethane-1,2-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylphenyl)ethane-1,2-diol(146566-05-4)
• EPA Substance Registry System: 1-(4-methylphenyl)ethane-1,2-diol(146566-05-4)

Safety Data

• Hazardous Substances Data: 146566-05-4(Hazardous Substances Data)

Upstream product

• 622-97-9 1-ethenyl-4-methylbenzene 
• 13107-39-6 2-(4-methylphenyl)oxirane 
• 98750-11-9 2-hydroxy-2-(4-methylphenyl)ethyl acetate 
• 34867-87-3 spirocyclobutylmalonoyl peroxide 
• 4079-54-3 2-hydroxy-1-p-tolyl-ethanone 
• 619-41-0 4-(bromoacetyl)toluene 
• 13603-62-8 1-(4-methylphenyl)-1,2-ethanediol 
• 35675-44-6 4-methylphenylacetyl chloride 
• 1505-50-6 3-(4-Methylphenyl)propanoic acid 
• 100-52-7 benzaldehyde 
• 104-87-0 4-methyl-benzaldehyde 
• 766-97-2 4-n-methylphenylacetylene 
• 4186-14-5 1-(2-(trimethylsilyl)ethynyl)toluene 
• 106-38-7 para-bromotoluene 

Downstream Products

• 14471-82-0 3-(4-methyl-benzyl)-1,1-dioxo-6-trifluoromethyl-1,2,3,4-tetrahydro-1λ⁶-benzo[1,2,4]thiadiazine-7-sulfonic acid amide 
• 201403-01-2 (p-Methylphenyl)-1,2-ethane cyclic carbonate 
• 18584-20-8 (R)-para-methylmandelic acid 
• 139016-20-9 (S)-1-(4-methylphenyl)-1,2-ethanediol 
• 179914-05-7 (R)-1-(4-methylphenyl)-1,2-ethanediol 
• 4079-54-3 2-hydroxy-1-p-tolyl-ethanone 
• 17286-62-3 2-(4-methylphenyl)quinoxaline 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 34966-53-5 methyl 4-methylphenylglyoxylate 
• 97642-98-3 (R)-1-(4'-methylphenyl)-2-aminoethanol 
• 149403-05-4 (S)-1-(4'-methylphenyl)-2-aminoethanol 

Relevant articles and documents

Exploiting Designed Oxidase-Peroxygenase Mutual Benefit System for Asymmetric Cascade Reactions

A unique P450 monooxygenase-peroxygenase mutual benefit system was designed as the core element in the construction of a biocatalytic cascade reaction sequence leading from 3-phenyl propionic acid to (R)-phenyl glycol. In this system, P450 monooxygenase (P450-BM3) and P450 peroxygenase (OleTJE) not only function as catalysts for the crucial initial reactions, they also ensure an internal in situ H2O2 recycle mechanism that avoids its accumulation and thus prevents possible toxic effects. By directed evolution of P450-BM3 as the catalyst in the enantioselective epoxidation of the styrene-intermediate, formed from 3-phenyl propionic acid, and the epoxide hydrolase ANEH for final hydrolytic ring opening, (R)-phenyl glycol and 9 derivatives thereof were synthesized from the respective carboxylic acids in one-pot processes with high enantioselectivity.

Catalytic Diastereo- and Enantioconvergent Synthesis of Vicinal Diamines from Diols through Borrowing Hydrogen

We present herein an unprecedented diastereoconvergent synthesis of vicinal diamines from diols through an economical, redox-neutral process. Under cooperative ruthenium and Lewis acid catalysis, readily available anilines and 1,2-diols (as a mixture of diastereomers) couple to forge two C?N bonds in an efficient and diastereoselective fashion. By identifying an effective chiral iridium/phosphoric acid co-catalyzed procedure, the first enantioconvergent double amination of racemic 1,2-diols has also been achieved, resulting in a practical access to highly valuable enantioenriched vicinal diamines.

Method for synthesizing chiral 1,2-diol compound

The invention relates to a method for synthesizing a chiral 1,2-diol compound, which comprises the following steps: sequentially adding a cobalt catalyst, a ligand, alpha-hydroxy ketone, an organic solvent and silane into a reaction system at 20-30 DEG C in a nitrogen atmosphere, then stirring the mixture, and carrying out column chromatography separation on the obtained product to obtain the chiral 1,2-diol compound. The high-yield cobalt catalyst in the earth crust is used, meanwhile, cheap silane (PMHS, 500 g/298 yuan) is used as a reducing agent, the asymmetric reduction reaction of alpha-hydroxy ketone can be efficiently achieved under the mild condition, and the chiral 1,2-diol compound with high yield and optical activity is obtained. Moreover, through the creative labor of the inventor, the reaction yield can reach 99%, and meanwhile, the content of the target product in the generated reaction product is 99% (namely, the yield is 99%, 99% ee).