146575-64-6

Basic information

• Product Name: 1-(2-HYDROXY-5-TRIFLUOROMETHOXY-PHENYL)-ETHANONE
• Synonyms: 2'-HYDROXY-5'-(TRIFLUOROMETHOXY)ACETOPHENONE;2-HYDROXY-5-(TRIFLUOROMETHOXY)ACETOPHENONE;1-(2-HYDROXY-5-TRIFLUOROMETHOXY-PHENYL)-ETHANONE;1-[2-Hydroxy-5-(trifluoromethoxy)phenyl]ethan-1-one, 2-Acetyl-4-(trifluoromethoxy)phenol
• CAS NO: 146575-64-6
• Molecular Formula: C9H7F3O3
• Molecular Weight: 220.15
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 146575-64-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 28-31℃
• Boiling Point: 231.4°Cat760mmHg
• Flash Point: 93.7°C
• Appearance: /
• Density: 1.377g/cm³
• Vapor Pressure: 0.0412mmHg at 25°C
• Refractive Index: 1.478
• PKA: 9.55±0.18(Predicted)
• CAS DataBase Reference: 1-(2-HYDROXY-5-TRIFLUOROMETHOXY-PHENYL)-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-HYDROXY-5-TRIFLUOROMETHOXY-PHENYL)-ETHANONE(146575-64-6)
• EPA Substance Registry System: 1-(2-HYDROXY-5-TRIFLUOROMETHOXY-PHENYL)-ETHANONE(146575-64-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 146575-64-6(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of pyridinium dichromate with 4-trifluoromethoxy-2-(a-hydroxyethyl)phenol in the presence of Celite in methylene chloride at r.t. (85%).

InChI:InChI=1/C9H7F3O3/c1-5(13)7-4-6(2-3-8(7)14)15-9(10,11)12/h2-4,14H,1H3

Upstream product

• 93249-62-8 2-hydroxy-5-(trifluoromethoxy)benzaldehyde 
• 1345731-90-9 2'-(methoxymethoxy)-5'-(trifluoromethoxy)acetophenone 
• 1345731-89-6 1-[2-(methoxymethoxy)-5-(trifluoromethoxy)phenyl]ethanol 
• 162270-05-5 2-(methoxymethoxy)-5-(trifluoromethoxy)benzaldehyde 

Relevant articles and documents

Discovery of potent selective orally active benzoxazepine-based orexin-2 receptor antagonists

During our efforts to identify a series of potent, selective, orally active human Orexin-2 Receptor (OX2R) antagonists, we elucidated structure-activity relationship (SAR) on the 7-position of a benzoxazepine scaffold by utilizing Hammett rp and Hansch-Fu

Benzopyran derivatives and processes for the preparation thereof

The present invention relates to novel benzopyran derivatives of formula (I) which have superior selectivity in the treatment of hypertension by lowering blood pressure with a relaxation activity on vascular smooth muscle. The present invention also relat

Novel benzopyran derivatives and processes for the preparation thereof

The present invention relates to novel benzopyran derivatives of formula(I) which have exellent effectiveness in the treatment of asthma as well as hypertension. The present invention also relates to processes for preparing such compounds and to pharmaceutical compositions containing such compounds as an effective ingredient: wherein: R1 is-CN, -NO2, -OCX1X2X3, -NH2, -NHSO2RA, -SO2RCor -SO2NRCRDwherein X1, X2 and X3 are, each independently, F, Cl or H, except for that X1, X2 and X3 may not be hydrogen atom simulaneously; RAand RBare, each independently, a hydrogen atom, or a C1 6 alkyl group or an optionally substituted phenyl group with a halogen atom, or a straight or branched C1 3 alkyl group; and RCand RDare, each independently, a hydrogen atom or a C1 6 alkyl group or an optionally substituted phenyl group with a halogen atom, or a straight or branched C1 3 alkyl group; R2 isa C1 4 straight or branched alkyl group; R3 isa C1 4 straight or branched alkyl group, wherein RGand RHare, each independently, a C1 6 alkyl group or optionally substituted phenyl group with a halogen atom, or a straight or branched C1 3 alkyl group, A and B are, each independently, S or O; and Z is a C1 3 straight or branched alkyl group; X isN or N → O, provided, however, when X is in 2-position, R3 is and Y isa hydrogen or halogen atom, or an amino, hydroxy, a lower alkoxy or lower alkyl group.