146578-29-2

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 146578-28-1 Methyl 3,4-O-isopropylidene-2-O-(4-methoxybenzyl)-6-O-(2-methoxy-2-methylethyl)-1-thio-β-D-galactopyranoside 
• 118281-91-7 Methyl 3,4-O-isopropylidene-6-O-(2-methoxy-2-methylethyl)-1-thio-β-D-galactopyranoside 
• 108-24-7 acetic anhydride 
• 146578-30-5 Methyl 2-O-(4-methoxybenzyl)-1-thio-β-D-galactopyranoside 

Relevant academic research and scientific papers

Synthesis of tetrasaccharide building block of the O-specific polysaccharide of Shigella dysenteriae type 1

A glycosyl trichloroacetimidate derivative (1) of the tetrasaccharide α-D-Galp-(1→3)-α-D-GlcpNAc-(1→3)-α-L-Rhap-(1→3)-α-L-Rhap was synthesized in a highly stereoselective, stepwise manner, using methyl 1-thioglycosides of L-rhamnose, 2-azido-2-deoxy-D-glucose and D-galactose, as major intermediates. The protecting group scenario in compound 1 permits regioselective deblocking at its 'non-reducing end' unit. Therefore 1 is a suitable intermediate for the preparation of extended fragments of the title polysaccharide.