146578-99-6

Basic information

• Product Name: 2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline
• Synonyms: 2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline;2-Cyclopropyl-3-[(diphenylphosphinyl)Methyl]-4-(4-fluoropenyl)quinolin;2-Cyclopropyl-3-[(diphenylphosphinyl)Methyl]-4-(4-fluorophenyl)quinolin;Diphenyl[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]Methylphosphine oxide;2-cyclopropyl-3-((diphenylphosphoryl)Methyl)-4-(4-fluorophenyl)quinoline;Quinoline,2-cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)-;PB3;2-Cyclopropyl-3-[(diphenylphosphinyl)
• CAS NO: 146578-99-6
• Molecular Formula: C₃₁H₂₅FNOP
• Molecular Weight: 477.517
• EINECS: 1806241-263-5
• Mol File: 146578-99-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 644.276 °C at 760 mmHg
• Flash Point: 343.446 °C
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.40±0.50(Predicted)
• CAS DataBase Reference: 2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline(146578-99-6)
• EPA Substance Registry System: 2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline(146578-99-6)

Safety Data

• Hazardous Substances Data: 146578-99-6(Hazardous Substances Data)

Usage

General Description

2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline is a compound with the chemical formula C29H24FNP and a molecular weight of 415.5 g/mol. It is a quinoline derivative that contains a cyclopropyl group, a diphenylphosphinylmethyl group, and a 4-fluorophenyl group. 2-Cyclopropyl-3-[(diphenylphosphinyl)methyl]-4-(4-fluorophenyl)quinoline may have potential pharmaceutical applications due to its structural features and may exhibit biological activities such as antimicrobial or anticancer properties. Further research and studies are required to fully understand its potential uses and biological effects.

InChI:InChI=1/C31H25FNOP/c32-24-19-17-22(18-20-24)30-27-13-7-8-14-29(27)33(34)31(23-15-16-23)28(30)21-35(25-9-3-1-4-10-25)26-11-5-2-6-12-26/h1-14,17-20,23H,15-16,21H2

Upstream product

• 121660-37-5 2-cyclopropyl-4-(4-fluorophenyl)-3-formylquinoline 
• 1079-66-9 chloro-diphenylphosphine 
• 121660-11-5 2-cyclopropyl-4-(4-fluorophenyl)-3-(hydroxymethyl)quinoline 
• 1733-55-7 ethyl diphenylphosphinate 
• 154057-56-4 3-(bromomethyl)-2-cyclopropyl-4-(4-fluorophenyl)-quinoline 
• 719-80-2 Ethyl diphenylphosphinite 

Downstream Products

• 147489-06-3 (4R,6S)-(E)-{6-[2-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-vinyl]-2,2-dimethyl-1,3-dioxan-4-yl}acetic acid tert-butyl ester 
• 146579-01-3 ((4S,6R)-6-{(E)-2-[2-Cyclopropyl-4-(4-fluoro-phenyl)-quinolin-3-yl]-vinyl}-2,2-dimethyl-[1,3]dioxan-4-yl)-acetic acid methyl ester 
• 141750-59-6 (3S,5R,6E)-7-<2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl>-3,5-dihydroxy-6-heptenoic acid ,15-lactone 
• 1391833-12-7 (4R,6S)-4-{[tert-butyl(dimethyl)silyl]oxy}-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}tetrahydro-2H-pyran-2-one 
• 574705-92-3 sodium (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxyhept-6-enoate 
• 148516-15-8 (6S)-6-{(E)-2-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]vinyl}-5,6-dihydro-2H-pyran-2-one 
• 147526-32-7 pitavastatin calcium salt 

Relevant articles and documents

Palladium-Catalyzed Stereoselective Cyclization of in Situ Formed Allenyl Hemiacetals: Synthesis of Rosuvastatin and Pitavastatin

A diastereoselective palladium-catalyzed cyclization of allenyl hemiacetals is described. It permits the selective synthesis of 1,3-dioxane derivatives, precursors for syn-configured 1,3-diols which make an appearance in all of the statin representatives. The reaction allows the total synthesis of Rosuvastatin and Pitavastatin in a straightforward fashion.

Synthesis of artificial HMG-CoA reductase inhibitors based on the olefination strategy

Synthetic methods were studied for optically active 6-oxo-3,5-isopropylidenedioxyhexanoate esters (4), which could be used as a key precursor of various kinds of artificial analogs of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. An enantiomer (+)-4 was prepared by asymmetric reduction of β,δ-diketo esters derived from the Taber's alcohol or L-tartrate followed by a series of chemical transformations, and the desired enantiomer (-)-4 was prepared by the same asymmetric reduction starting from D-tartrate. The key intermediate (-)-4 was finally converted into a highly potent HMG-CoA reductase inhibitor, NK-104.