146581-50-2

Upstream product

• 4381-25-3 S-methyl-S-phenylsulfoximine 
• 106-95-6 allyl bromide 

Downstream Products

• 860770-10-1 C₁₄H₁₉NOS 
• 1200799-55-8 C₁₄H₁₇NO₂S 
• 1200799-54-7 C₁₄H₁₇NO₂S 
• 1402750-80-4 S-(2-(furan-2-yl)ethyl)-S-phenylsulfoximine 
• 1402750-63-3 S-phenyl-S-vinyl-N-(2-methylallyl)sulfoximine 
• 1402750-73-5 (E)-S-2-(furan-2-yl)vinyl-S-phenyl-N-allylsulfoximine 
• 860770-12-3 C₁₅H₂₁NOS 

Relevant academic research and scientific papers

N-alkylations of NH-sulfoximines and NH-sulfondiimines with alkyl halides mediated by potassium hydroxide in dimethyl sulfoxide

A general method for the N-alkylation of NH-sulfoximines and NH-sulfondiimines has been developed, employing alkyl bromides with KOH in DMSO at room temperature. A variety of previously inaccessible N-alkylated sulfoximines and sulfondiimines was prepared in good to excellent yields (up to 97%). As an application, the conditions were used to access the biologically active Suloxifen.

C-H activation in S-alkenyl sulfoximines: An endo 1,5-hydrogen migration

Intramolecular redox reaction: Heating N-alkyl, N-allyl-, and N-benzyl-substituted S-alkenyl sulfoximines under appropriate conditions results in the formation of NH-S-alkyl sulfoximines. The intramolecular redox reaction involves a hydride transfer that occurs by a 6-endo-trig process. The intermediates in the reaction can also give access to four- and six-membered heterocyclic rings and a new class of chiral dienes. Copyright

Ring-closing metathesis (RCM) for the synthesis of cyclic sulfoximines

Chiral heterocycles can be prepared starting from doubly unsaturated sulfoximine derivatives by ring-closing metathesis reaction in good yields. Georg Thieme Verlag Stuttgart.