1466-74-6

Basic information

• Product Name: 4-PHENYLCYCLOHEXANECARBOXALDEHYDE
• Synonyms: 4-PHENYLCYCLOHEXANECARBOXALDEHYDE;4-Phenylcyclohexanecarbaldehyde
• CAS NO: 1466-74-6
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 188.27
• Mol File: 1466-74-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 297.6°Cat760mmHg
• Flash Point: 105.5°C
• Appearance: /
• Density: 1.062g/cm³
• Vapor Pressure: 0.00134mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 4-PHENYLCYCLOHEXANECARBOXALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYLCYCLOHEXANECARBOXALDEHYDE(1466-74-6)
• EPA Substance Registry System: 4-PHENYLCYCLOHEXANECARBOXALDEHYDE(1466-74-6)

Safety Data

• Hazardous Substances Data: 1466-74-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C13H16O/c14-10-11-6-8-13(9-7-11)12-4-2-1-3-5-12/h1-5,10-11,13H,6-9H2

Upstream product

• 4894-75-1 1-phenyl-4-cyclohexanone 
• 701232-23-7 [4-(methoxymethylidene)cyclohexyl]benzene 
• 697306-44-8 N-methoxy-N-methyl-4-phenylcyclohexanecarboxamide 

Downstream Products

• 698390-60-2 (2R,3S)-N-{3-[(dimethylamino)methyl]phenyl}-3-(1H-indol-3-yl)-2-{[(4-phenylcyclohexyl)methyl]amino}butanamide 
• 1253039-12-1 2-(4-phenylcyclohexylidene)-1,3-dithiane 1-oxide 
• 5437-46-7 trans-4-phenylcyclohexanol 
• 7335-12-8 cis-4-phenylcyclohexanol 
• 87073-90-3 ((1r,4r)-4-phenylcyclohexyl)methanol 
• 1593076-77-7 C₂₀H₂₇BrO₃ 
• 701232-25-9 methyl 3-((trans)-4-phenylcyclohexyl)propanoate 
• 32274-07-0 4-phenylcyclohexane-1-carbonitrile 

Relevant articles and documents

TRICYCLIC COMPOUND SERVING AS IMMUNOMODULATOR

Provided are compounds of formula I and formula II or pharmaceutically acceptable salts of the compounds and pharmaceutical compositions thereof. The compounds of formula I and formula II or the pharmaceutically acceptable salts of the compounds provide indole 2,3-dioxygenase (IDO) inhibitory activity and are capable of treating IDO-mediated immunosuppressive diseases, such as infectious diseases or cancer.

Discovery of 6-phenylpyrimido[4,5- B ][1,4]oxazines as potent and selective Acyl CoA: Diacylglycerol acyltransferase 1 (DGAT1) inhibitors with in vivo efficacy in rodents

The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is described. The SAR of a moderately potent HTS hit was investigated resulting in the discovery of phenylcyclohexylacetic acid 1, which displayed good DGAT1 inhibitory activity, selectivity, and PK properties. During preclinical toxicity studies a metabolite of 1 was observed that was responsible for elevating the levels of liver enzymes ALT and AST. Subsequently, analogues were synthesized to preclude the formation of the toxic metabolite. This effort resulted in the discovery of spiroindane 42, which displayed significantly improved DGAT1 inhibition compared to 1. Spiroindane 42 was well tolerated in rodents in vivo, demonstrated efficacy in an oral triglyceride uptake study in mice, and had an acceptable safety profile in preclinical toxicity studies.

Potassium dodecatangestocobaltate trihydrate (K5CoW12O40·3H2O): A mild and efficient catalyst for deprotection of dioxolanes and trimethylsilyl ethers

Mild and easy deprotection of benzylic dioxolanes to carbonyl compounds (in refluxing dry acetone) and trimethylsilyl ethers to alcohols in acetonitrile at ambient temperature has been carried out in excellent yields under K5CoW12O40·3H2O (0.01 molar equiv.) catalysis.