146604-16-2

Upstream product

• 876173-54-5 tert-butyl-(5-methoxy-3-vinyl-tetrahydro-furan-2-ylmethoxy)-diphenyl-silane 
• 99315-76-1 (5S)-5-(tert-butyldiphenylsiloxymethyl)-2(5H)-furanone 
• 78508-96-0 (5S)-5-(hydroxymethyl)-5H-furan-2-one 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 140209-45-6 (4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-vinyl-dihydro-furan-2-one 

Downstream Products

• 876173-65-8 tert-butyl-diphenyl-{5-phenylselanyl-3-[1-(4,4,7a-trimethyl-octahydro-inden-1-yl)-vinyl]-tetrahydro-furan-2-ylmethoxy}-silane 
• 876173-58-9 tert-butyl-{5-methoxy-3-[1-(4,4,7a-trimethyl-octahydro-inden-1-yl)-vinyl]-tetrahydro-furan-2-ylmethoxy}-diphenyl-silane 
• 876173-57-8 [2-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxy-tetrahydro-furan-3-yl]-(4,4,7a-trimethyl-octahydro-inden-1-yl)-methanone 
• 876173-56-7 [2-(tert-butyl-diphenyl-silanyloxymethyl)-5-methoxy-tetrahydro-furan-3-yl]-(4,4,7a-trimethyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)-methanone 

Relevant academic research and scientific papers

Norrisolide: Total synthesis and related studies

A stereoselective synthesis of (+)-norrisolide is presented. This natural product belongs to a family of marine spongiane diterpenes the structure of which is characterized by a fused γ-lactone-γ-lactol ring system attached to a bicyclic hydrophobic core.

Backbone modified oligonucleotide analogs

Oligonucleotide analogs are provided wherein phosphodiester inter-sugar linkages are replaced with four atom linking groups. Such linking groups include NR--C(O)--CH2 --CH2, NR--C(S)--CH2 --CH2, CH2 --NR--C(O)--CH2, CH2 --NR--C(S)--CH2, CH2 --CH2 --NR--C(O)--R--CH2, and CH2 --C(S)--NR--CH2. Methods for preparing and using these oligonucleotide analogs are also provided.