146607-46-7Relevant academic research and scientific papers
Synthetic studies on naturally occurring coumarins. II. Synthesis of 6,7-dimethoxy- and 7,8-dimethoxy-5-[(E)-3-oxo-1-butenyl]coumarins
Ishii,Ishikawa,Wada,Miyazaki,Kaneko,Harayama
, p. 2614 - 2619 (2007/10/02)
In connection with studies on the structure elucidation of the so-called Reisch's coumarin isolated from Toddalia asiatica, syntheses of two coumarins (4 and 5) were accomplished via the routes shown in Charts 2 and 3, respectively. Melting points and NMR data of the synthesized coumarins (4 and 5) and of related coumarins (5-methoxysuberenon, toddalenone, and Reisch's coumarin) are given in Table I, suggesting that so-called Reisch's coumarin might be 4.
A convenient synthesis of a simple coumarin
Ishii,Kaneko,Miyazaki,Harayama
, p. 3100 - 3102 (2007/10/02)
Reaction of salicylaldehydes (1) with carbethoxymethylenephosphorane in diethylaniline under reflux gave coumarins (3) in excellent yields. Methoxy substituent at C'4 on salicylaldehyde (1) facilitated the formation of coumarin from trans-cinnamate (2), which is first prepared by reaction of 1 with Wittig reagent.
