146609-08-7

Basic information

• Product Name: 2-amino-9-[(2S,4R)-4-(hydroxymethyl)tetrahydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one
• CAS NO: 146609-08-7
• Molecular Formula: C₁₀H₁₃N₅O₃
• Molecular Weight: 251.2419
• Mol File: 146609-08-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 632.1°C at 760 mmHg
• Flash Point: 336.1°C
• Density: 1.91g/cm³
• Vapor Pressure: 7.6E-17mmHg at 25°C
• Refractive Index: 1.863
• CAS DataBase Reference: 2-amino-9-[(2S,4R)-4-(hydroxymethyl)tetrahydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-9-[(2S,4R)-4-(hydroxymethyl)tetrahydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one(146609-08-7)
• EPA Substance Registry System: 2-amino-9-[(2S,4R)-4-(hydroxymethyl)tetrahydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one(146609-08-7)

Safety Data

• Hazardous Substances Data: 146609-08-7(Hazardous Substances Data)

Upstream product

• 112233-74-6 N₂-acetyl-O₆-(diphenylcarbamoyl)guanine 
• 146558-05-6 2-N-acetyl-6-O-(diphenylcarbamoyl)guanine 
• 155165-00-7 5(S)-<2-(acetylamino)-6-(diphenylcarbamoyloxy)-9H-purin-6-yl>tetrahydro-3(S)-<(acetyloxy)methyl>furan 
• 485815-81-4 Benzoic acid 5-methoxy-tetrahydro-furan-3-ylmethyl ester 
• 143724-42-9 (rel)-(1S/1R,3S)-(tetrahydro-1-methoxyfuran-3-yl)methanol 
• 99776-32-6 2-(hydroxymethyl)-4,4-dimethoxybutan-1-ol 
• 132813-80-0 Benzoic acid (3R,5R)-5-(2-amino-6-chloro-purin-9-yl)-tetrahydro-furan-3-ylmethyl ester 
• 132813-80-0 Benzoic acid (3S,5R)-5-(2-amino-6-chloro-purin-9-yl)-tetrahydro-furan-3-ylmethyl ester 

Relevant articles and documents

Synthetic approaches to novel cis and trans dideoxynucleosides of the apiose family

Stereoselective synthesis of the complete family of optically active dideoxygenated nucleosides of the apiose family have been developed. The chiral aldodiol system 7, a key intermediate in this synthesis, was prepared from the prochiral molecule 6, through the action of the lipase from Candida cylindracia. Approaches to novel enantiomeric and diastereoisomeric dideoxynucleosides containing the tetrahydrofuranethanol moiety have also been discovered. A key intermediate in this approach was the optically active trans-allyllactone 61, prepared from L-glutamic acid, and its isomerization product, the corresponding cis-allylbutyrolactone 62. The methodologies developed have generality and allow synthetic access to a wide variety of new nucleosides.

SYNTHESIS OF (+/-)-2'-OXA-CARBOCYCLIC-2',3'-DIDEOXYNUCLEOSIDES AS POTENTIAL ANTI-HIV AGENTS

Novel 2',3'-dideoxynucleosides, having the pentofuranosyl oxygen at the 2'-position, were obtained by a short synthetic route from diethyl malonate and bromoacetalehyde dimethyl acetal.The results of biological testing against HIV-1 in vitro are presented.