146651-71-0

Basic information

• Product Name: tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate
• Synonyms: tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate;[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]-1,1-dimethylethyl Carbamic acid ester
• CAS NO: 146651-71-0
• Molecular Formula: C₉H₁₉NO₅
• Molecular Weight: 221.25086
• Mol File: 146651-71-0.mol
• Article Data: 49

Chemical Properties

• Melting Point: 144-146 °C(Solv: tetrahydrofuran (109-99-9))
• Boiling Point: 430.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1 +-.0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.66±0.46(Predicted)
• CAS DataBase Reference: tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate(146651-71-0)
• EPA Substance Registry System: tert-Butyl N-[2-hydroxy-1,1-bis(hydroxymethyl)-ethyl]carbamate(146651-71-0)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 146651-71-0(Hazardous Substances Data)

Usage

Description

N-Boc-Tris contains an acid labile, Boc protecting group.

Upstream product

• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 77-86-1 2-amino-2-hydroxymethyl-1,3-propanediol 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 885605-36-7 5-(tert-butyloxycarbonylamino)-2,2-dimethyl-5-(4-octylphenethyl)-1,3-dioxane 
• 1033408-71-7 tert-butyl (2,2-dimethyl-5-phenethyl-1,3-dioxan-5-yl)carbamate 
• 1384881-45-1 C₄₁H₆₂N₂O₈Si 

Relevant articles and documents

Multidentate polysarcosine-based ligands for water-soluble quantum dots

We describe the synthesis of heterotelechelic polysarcosine polymers and their use as multidentate ligands in the preparation of stable water-soluble quantum dots (QDs). Orthogonally functionalized polysarcosine with amine and dibenzocyclooctyl (DBCO) end groups is obtained by ring-opening polymerization of N-methylglycine N-carboxyanhydride with DBCO amine as initiator. In a first postpolymerization modification step, the future biological activity of the polymeric ligands is adjusted by modification of the amine terminus. Then, in a second postpolymerization modification step, azide functionalized di- and tridentate anchor compounds are introduced to the DBCO terminus of the polysarcosine via strain-promoted azide-alkyne cycloaddition (SPAAC). Through the separate synthesis of the anchor compounds, it is possible to ensure reproducible introduction of a well-defined number of multiple anchor groups to all polymers studied. Finally, the obtained multidentate polymeric ligands are successfully used in the ligand exchange procedures to yield stable, water-soluble QDs. As polysarcosine-based ligands can provide biocompatibility, prevent nonspecific interactions, and simultaneously enable specific targeting, the systems presented here are promising candidates to provide QDs well suitable for ex vivo analytics or bioimaging.

Click inspired synthesis of hexa and octadecavalent peripheral galactosylated glycodendrimers and their possible therapeutic applications

A Cu(i)-catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction (CuAAC) has been utilized for the synthesis of novel glycodendrimers containing a rigid hexapropargyloxy benzene centered core with 6- and 18-peripheral β-d-galactopyranosidic units. Struct

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N-tert-butoxycarbonyl (BOC) protected [V6O13{(OCH2)3CNH2}2]2?: synthesis, structural characterization, and solution behavior

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PHOSPHATE DERIVATIVES AND USE THEREOF

The present invention discloses a compound with the following formula (I), or a tautomer, mesomer, racemate, enantiomer, and diastereoisomer thereof, or a mixture form thereof, or a pharmaceutically acceptable salt thereof, or a prodrug molecule thereof, wherein D is selected from: The invention further discloses the use of the compound in the preparation of drugs for preventing and/or treating cancers, and the use of the compound in the preparation of drugs for inhibiting cancer metastasis. The compound of the present invention can effectively inhibit the proliferation and metastasis of cancer cells by adjusting the acidity of a tumor microenvironment to achieve a better effect in clinical cancer treatment, and has broad application prospects.

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The invention relates to a method for chemically synthesizing dendritic glycosamine containing various sugars by gradient click chemistry, which can be used for post-modification of a polymer skeletoncontaining active ester. The method comprises the steps of reacting di-tert-butyl dicarbonate (Diboc) with tris (hydroxymethyl) aminomethane (THAM), and protecting amino in the tris (hydroxymethyl) aminomethane (THAM) by using tert-butyloxycarbonyl; then introducing three terminal alkyne at the tail end of the compound by utilizing Williessen ether-forming reaction; and carrying out gradient CuAAC reaction on terminal alkyne and acetyl protected azido sugar, and finally, removing Boc group protection by trifluoroacetic acid. Compared with the prior art, the method provided by the invention utilizes the advantages of CuAAC click chemistry, provides a simple and rapid approach for synthesis of heterogeneous glycosamines containing a variety of glycosyls, and has an important guiding significance for preparation of multifunctional heterogeneous glycopolymers with ordered structures and controllable molecular weights.

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