1466534-31-5Relevant articles and documents
Three-step synthesis of triazolobenzodiazepinones via sonogashira/huisgen protocol
Molteni, Giorgio
, p. 1765 - 1773 (2013/09/12)
The sequential Sonogashira coupling/intramolecular azide cycloaddition (Huisgen cycloaddition) protocol was performed onto N-(2-iodophenyl)- 2-azidoacetamide as the acyclic precursor giving tricyclic 1,2,3-triazolo- [5,1-d][1,4]benzodiazepin-2-ones. These target products were thus obtained through a three-step synthesis in variable yields depending upon the substituent placed onto the acetylenic counterpart. The influence of catalyst concentration, reaction temperature and reaction medium upon cycloadduct yields were also studied.