146668-87-3Relevant academic research and scientific papers
A Practical Synthesis of Perdeuterated Deoxyribose and Deoxyribonucleosides
Goering, Brad K.,Lee, Kwangjin,An, Byungjae,Cha, Jin K.
, p. 1100 - 1103 (2007/10/02)
A stereoselective synthesis of perdeuterated deoxyribofuranoside (1) has been developed starting from known methyl 4-(2'-tetrahydropyranyloxy)-2-butynoate.The synthetic strategy involved the Sharpless asymmetric epoxidation of alcohol 7, followed by a tandem epoxide isomerization and opening with NaCN.The resulting lactone 4b was then reduced via its TBDMS derivative with Dibal-D and subsequently converted to perdeuterated deoxyribofuranoside (1).
