146672-58-4

Basic information

• Product Name: PAPA NONOATE
• Synonyms: 3-(2-HYDROXY-2-NITROSO-1-PROPYLHYDRAZINO)-1-PROPANAMINE NONOATE;1-HYDROXY-2-OXO-3-(3-AMINOPROPYL)-3-PROPYL-1-TRIAZENE;(Z)-1-[N-(3-AMMONIOPROPYL)-N-(N-PROPYL)AMINO]DIAZEN-1-IUM-1,2-DIOLATE;(Z)-1-[N-(3-AMINOPROPYL)-N-)B-PROPYL)AMINO]DIAZIN-1-IUM-1,2-DIOLATE;PROPYLAMINE PROPYLAMINE NONOATE;PAPA/NO;PAPA NONOATE;NOC-15
• CAS NO: 146672-58-4
• Molecular Formula: C6H16N4O2
• Molecular Weight: 176.22
• Mol File: 146672-58-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 277.2°Cat760mmHg
• Flash Point: 121.4°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 0.000569mmHg at 25°C
• Storage Temp.: -20°C
• Solubility: Soluble in Water or Ethanol.
• Stability: Stable for 1 year from date of purchase as supplied. Protect from exposure to air or moisture. Solutions are not stable and must be prepared immediately before use.
• CAS DataBase Reference: PAPA NONOATE(CAS DataBase Reference)
• NIST Chemistry Reference: PAPA NONOATE(146672-58-4)
• EPA Substance Registry System: PAPA NONOATE(146672-58-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 146672-58-4(Hazardous Substances Data)

Usage

Description

PAPA NONOate (146672-58-4) is a nitric oxide donor and dissociates to the free amine and NO in a pH dependent manner. The half-life of PAPA NONOate in 0.1 M phosphate buffer at pH 7.4 is 15 minutes at 37°C, or 77 minutes at room temperature.1?Dissociation is essentially instantaneous at a pH of 5.0.

Uses

PAPA NONOate is an NO donor which suppresses the caspase apoptotic cascade.

References

1) Keefer?et al. (1996),?‘NONOates’ (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms; Methods Enzymol.,?268?281

InChI:InChI=1/C6H16N4O2/c1-2-5-9(6-3-4-7)10(12)8-11/h12H,2-7H2,1H3/p+1