146679-66-5

Basic information

• Product Name: 3-Bromopyridine-4-methanol
• Synonyms: 3-Bromopyridine-4-methanol;3-Bromo-4-pyridinemethanol;3-Bromo-4-(hydroxymethyl)pyridine;(3-Bromo-4-pyridyl)methanol;4-PyridineMethanol, 3-broMo-;(3-Bromopyridin-4-yl)
• CAS NO: 146679-66-5
• Molecular Formula: C₆H₆BrNO
• Molecular Weight: 188.023
• Mol File: 146679-66-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 287.079oC at 760 mmHg
• Flash Point: 127.421oC
• Appearance: /
• Density: 1.669g/cm3
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.72±0.10(Predicted)
• CAS DataBase Reference: 3-Bromopyridine-4-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromopyridine-4-methanol(146679-66-5)
• EPA Substance Registry System: 3-Bromopyridine-4-methanol(146679-66-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 146679-66-5(Hazardous Substances Data)

Usage

General Description

3-Bromopyridine-4-methanol, also known as 4-(3-Bromopyridin-4-yloxy)methanol, is a chemical compound with the molecular formula C6H6BrNO. It is a derivative of pyridine, a heterocyclic aromatic compound, with a bromine atom and a hydroxyl group attached to the fourth position of the pyridine ring. 3-Bromopyridine-4-methanol is used in the synthesis of various pharmaceuticals and agrochemicals, and it also serves as a building block for the preparation of other organic compounds. Its unique structure and reactivity make it a valuable intermediate in organic synthesis and a useful tool for chemical research. Additionally, 3-Bromopyridine-4-methanol has potential applications in medicinal chemistry and drug discovery due to its pharmacological properties.

InChI:InChI=1/C6H6BrNO/c7-6-3-8-2-1-5(6)4-9/h1-3,9H,4H2

Upstream product

• 70201-43-3 3-bromo-pyridine-4-carbaldehyde 
• 13959-02-9 3-bromoisonicotinic acid 
• 79-22-1 methyl chloroformate 

Downstream Products

• 1017599-02-8 1'-benzyl-4-hydroxymethyl-2',3',5',6'-tetrahydro-1'H-[3,4']bipyridinyl-4'-ol 
• 1037830-81-1 3-bromo-4-(2-iodo-phenoxymethyl)-pyridine 
• 1357095-16-9 3-bromo-4-(methoxymethyl)pyridine 

Relevant articles and documents

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A compound of the formula (I) in which the dotted lines indicate the presence of at least one double bond; n = 0 to 4; R3 and R4 are H, or when n = 1, R3 and R4 can also form together a double bond between the carbon atoms, and m = 0, 1 or 2, Z is CH or N or Z is C and -CHR3- is =CH- linked by the double bond to the cyclopentanone; or -(-)m- is absent, and Z is NH, >N-alkyl, >N-phenyl, >N-benzyl or >N-heteroaryl; R8 is alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR', CN, COR, CF3, SOR, SO2R, SONRR', SO2NRR', NO2, halogen, heteroaryl; and the pharmaceutical salts or tautomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimer's disease.