146709-78-6

Basic information

• Product Name: 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE
• Synonyms: ZD 7155 HYDROCHLORIDE;5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE;5,7-Diethyl-3,4-dihydro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1,6-naphthyridin-2(1H)-onehydrochloride;ZD7155HCl
• CAS NO: 146709-78-6
• Molecular Formula: C₂₆H₂₆N₆O*ClH
• Molecular Weight: 474.99
• Mol File: 146709-78-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 746.4°Cat760mmHg
• Flash Point: 405.2°C
• Appearance: /
• Density: g/cm³
• Storage Temp.: Desiccate at +4°C
• CAS DataBase Reference: 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE(146709-78-6)
• EPA Substance Registry System: 5,7-DIETHYL-3,4-DIHYDRO-1-[[2'-(1H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1,6-NAPHTHYRIDIN-2(1H)-ONE HYDROCHLORIDE(146709-78-6)

Safety Data

• Hazardous Substances Data: 146709-78-6(Hazardous Substances Data)

Usage

Uses

ZD 7155 Hydrochloride, is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. it is shown to be more active than the prototype AT1 antagonist, losartan, and it’s orally active.

Biological Activity

A potent and selective competitive antagonist for the angiotensin II type 1 (AT 1 ) receptor. Displaces [ 125 I]-angiotensin II binding with an IC 50 value of 3.8 nM in guinea pig adrenal gland membranes. Orally active, and is more potent and longer-acting than the prototype AT 1 antagonist, losartan.

Upstream product

• 146720-84-5 5,7-Diethyl-1-[(2'-(1-(4-nitrophenyl)-1H-tetrazol-5-yl)-biphenyl-4-yl)methyl]-1,2,3,4-tetrahydro-1,6-naphthyridin-2-one 
• 146720-23-2 5.7-diethyl-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,2,3,4-tetrahydro-1,6-naphthyridin-2-one 

Relevant articles and documents

1,6-NAPHTHYRIDONE DERIVATIVES HAVING ANGIOTENSIN II ANTAGONIST ACTIVITY

The invention concerns pharmaceutically useful compounds of the formula I, in which R 1, R 2, R 3, R 4, Ra, Rb, A, X and Z have the various meanings defined herein, and their non-toxic salts, and pharmaceutical compositions containing them. The novel compounds are of value in treating conditions such as hypertension and congestive heart failure. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.