146723-95-7Relevant academic research and scientific papers
Synthesis and H2-antagonist properties of some 1,2,5-thiadiazole-1-oxide derivatives
Sorba,Di Stilo,Gasco,Gili,Gasco,Orsetti
, p. 1445 - 1455 (2007/10/02)
A series of 1,2,5-thiadiazole-1-oxide derivatives has been synthesized and studied for its H2-antagonist properties. These derivatives can be considered derived from classical H2-antagonists in which the structure was deeply modified in order to evidence the minimal structural requirements for the activity. It was found that it is sufficient to have the 1,2,5-thiadiazole-1-oxide ring substituted with an alkylamino moiety and with an aliphatic chain linked to the hydroxy or ether group to achieve compounds as active as cimetidine. A few considerations on the binding on guinea-pig cerebral cortex of a series of H2-antagonists with more and more simplified structures are also reported.
