146724-94-9 Usage
Uses
Used in Neuronal Culture:
NOC-18 is used as a nitric oxide donor supplement for neuronal culture, aiding in the study and maintenance of neurons in laboratory settings.
Used in Protein S-Nitrosation Studies:
NOC-18 serves as a nitric oxide donor to investigate the effects of protein S-nitrosation (SNO) after nitrite treatment, contributing to the understanding of cellular processes and signaling pathways.
Used in Apoptosis Induction:
NOC-18 is utilized for inducing dose-dependent apoptosis in macrophages, which can be beneficial in studying immune cell behavior and the regulation of cell death.
Used in Inhibition of Lipoprotein Oxidation:
The compound is also used to inhibit lipoprotein oxidation induced by Cu2+ in vitro, which can help in understanding the role of nitric oxide in protecting cells from oxidative damage.
Chemical Properties:
NOC-18 appears as a white powder and is a nitric oxide donor with a half-life of 21 hours at 0.1mM in 0.1 M PBS at pH 7.4 and 37°C. It dissociates to the free amine and NO in a pH-dependent manner, with essentially instantaneous dissociation at a pH of 5.0.
Biochem/physiol Actions
3,3-Bis(aminoethyl)-1-hydroxy-2-oxo-1-triazene is a long-acting nitric oxide donor. It might exhibit nociceptive effects in rats.
Check Digit Verification of cas no
The CAS Registry Mumber 146724-94-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,7,2 and 4 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 146724-94:
(8*1)+(7*4)+(6*6)+(5*7)+(4*2)+(3*4)+(2*9)+(1*4)=149
149 % 10 = 9
So 146724-94-9 is a valid CAS Registry Number.
InChI:InChI=1/C4H13N5O2/c5-1-3-8(4-2-6)9(11)7-10/h11H,1-6H2/p+2
146724-94-9Relevant academic research and scientific papers
Competitive formation of N-diazeniumdiolates and N-nitrosamines via anaerobic reactions of polyamines with nitric oxide
Coneski, Peter N.,Schoenfisch, Mark H.
supporting information; experimental part, p. 5462 - 5465 (2010/02/28)
"Chemical Equation Presented" Reactions of amines with nitric oxide (NO) at high pressures form diverse NO donor species, highly dependent on the precursor structure. While monoamine precursors favor the formation of N-diazeniumdiolates in high yield, pol
