14673-58-6Relevant academic research and scientific papers
Synthesis and urease inhibitory activities of benzophenone semicarbazones/thiosemicarbazones
Arshia, Arshia,Khan, Ajmal,Khan, Khalid Mohammed,Saad, Syed Muhammad,Siddiqui, Nida Iqbal,Javaid, Sumaira,Perveen, Shahnaz,Choudhary, M. Iqbal
, p. 2666 - 2679 (2016)
Twenty-five benzophenone semicarbazones and thiosemicarbazones 3–27 were synthesized starting from benzophenones via hydrazones treated with different aryl isocyanates and isothiocyantes under reflux. All synthetic derivatives were evaluated for their urease inhibitory potential. Good to moderate inhibition trend against urease was observed with the IC50 values in the range of 8.7–119.5 μM, when compared with the standard thiourea (IC50 = 21.2 ± 1.3 μM). Compound 15 showed better inhibition than the standard having the IC50 value of 8.7 ± 0.6 μM. Compounds 3, 4, 8, 11–14, 16, and 17 with the IC50 values within the range of 26.1 to 43.6 μM, demonstrated good to moderate activities while compound 9 (IC50 = 119.5 ± 1.6 μM) displayed very weak activity. The enzyme kinetic studies on the most active compounds 15 and 17 were performed to deduce their modes of inhibition and dissociation constants Ki.
Zinc complex taking 2-benzoylpyridine thiosemicarbazone as ligand as well as synthesis method and application of zinc complex
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Paragraph 0010; 0059-0065, (2020/12/15)
The invention relates to a zinc complex taking 2-benzoylpyridine thiosemicarbazone as a ligand as well as a synthesis method and application of the zinc complex. The method comprises the steps of taking 2-benzoylpyridine and thiosemicarbazone, 4-methyl-3-thiosemicarbazone, 4,4'-dimethyl-3-thiosemicarbazide, 4-phenyl-3-thiosemicarbazide or 4-(2-methyl)phenyl-3-thiosemicarbazide as raw materials tosynthesize a schiff-base ligand; and reacting the ligand with zinc chloride to obtain the zinc complex. In an in-vitro test, the synthesized zinc complex has good inhibitory activity on human hepatomacarcinoma cells (HepG2), the treatment effect is superior to that of a clinical drug cis-platinum, and the zinc complex is suitable for preparing efficient antitumor drugs. In addition, the synthesized zinc complex has a good antibacterial effect on staphylococcus aureus, and is suitable for preparing antibacterial drugs.
Reactions of flavonoid thiosemicarbazones under acetylating conditions
Somogyi, Laszlo
, p. 9305 - 9316 (2007/10/02)
Upon acetylation, (2-phenyl)dihydrobenzopyrone- and 2′-hydroxychalcone thiosemicarbazones (1c, 2c, 3c, and 7c) form 2,2-disubstituted 5-acetamido-3-acetyl-2,3-dihydro-1,3,4-thiadiazoles (1i, 2i, 4i, and 8i) instead of the diacetylthiosemicarbazones (2e, 8
