146736-30-3Relevant academic research and scientific papers
2-AZA-BICYCLO[3.3.0]OCTANE DERIVATIVES
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Page/Page column 11, (2011/02/15)
The invention relates to 2-aza-bicyclo[3.3.0]octane derivatives of Formula (I) wherein A, B, and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.
TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES
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Page/Page column 50; 52, (2009/03/07)
The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.
Substituted benzaldehydes in the darzens condensation with alkyl dihaloacetates
Mamedov,Berdnikov,Tsuboi,Hamamoto,Komiyama,Gorbunova,Gubaidullin,Litvinov
, p. 1455 - 1463 (2007/10/03)
The Darzens reaction of dihaloacetic acid esters with aromatic aldehydes produces either arylhaloglycidic or arylhalopyruvic esters depending on the nature of the substituent in the aromatic ring. Alkyl p- methoxyphenylchloropyruvates undergo spontaneous intermolecular cyclocondensation to form pyranone or furanone derivatives depending on the character of the alkyl fragment.
CONDENSATION OF METHYL 2-CHLORO-3-(3-NITROPHENYL)-2,3-EPOXYPROPIONATE WITH 1,2-PHENYLENE DIAMINE
Mamedov, V. A.,Krokhina, L. V.,Il'yasov, A. V.
, p. 953 - 956 (2007/10/02)
It is established that the α-chloroepoxide methyl 2-chloro-3-(3-nitrophenyl)-2,3-epoxypropionate, in contrast to its α-chloroketone isomer methyl 3-(3-nitrophenyl)-3-chloro-2-oxopropionate, forms 2-(3-nitrophenyl)-3-methoxycarbonylquinoxaline in reaction
REACTION OF METHYL DICHLOROACETATE WITH SUBSTITUTED BENZALDEHYDES UNDER THE CONDITIONS OF THE DARZENS CONDENSATION
Mamedov, V. A.,Nuretdinov, I. A.
, p. 1690 - 1692 (2007/10/02)
We have found that condensation of methyl dichloroacetate (1) with benzaldehyde, p-chloro- and p-bromobenzaldehyde in t-BuOH in the presence of t-BuOK yields methyl 3-aryl-3-chloro-2-oxopropionates (3-5).In the case of nitrobenzaldehydes the reaction prod
