146747-40-2Relevant academic research and scientific papers
Synthesis of (+)- and (-)-nojirimycin and their 1-deoxy derivatives from myo-inositol
Chida,Furuno,Ikemoto,Ogawa
, p. 185 - 194 (2007/10/02)
The conversion of the naturally abundant cyclitol, myo-inositol (4), into (+)-nojirimycin (1a), its enantiomer (1b), and their 1-deoxy analogues (2a and 2b) is described. Biological assay of 2a, 2b, and the bisulfite adducts of 1a and 1b (3a and 3b) showed that the compounds having the unnatural L-gluco configuration (2b and 3b) possess moderate-to-high inhibitory activity against almond β-D-glucosidase and bovine liver β-D-galactosidase.
