146781-23-9

Basic information

• Product Name: 2,5-Difluoro-4-hydroxybenzoic acid
• Synonyms: 2,5-Difluoro-4-hydroxybenzoic acid
• CAS NO: 146781-23-9
• Molecular Formula: C7H4F2O3
• Molecular Weight: 174.1016664
• Mol File: 146781-23-9.mol
• Article Data: 5

Chemical Properties

• Melting Point: 163-165 °C(Solv: toluene (108-88-3))
• Boiling Point: 309.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.600±0.06 g/cm3(Predicted)
• PKA: 3.30±0.10(Predicted)
• CAS DataBase Reference: 2,5-Difluoro-4-hydroxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Difluoro-4-hydroxybenzoic acid(146781-23-9)
• EPA Substance Registry System: 2,5-Difluoro-4-hydroxybenzoic acid(146781-23-9)

Safety Data

• Hazardous Substances Data: 146781-23-9(Hazardous Substances Data)

Usage

General Description

2,5-Difluoro-4-hydroxybenzoic acid is a chemical compound that consists of a benzoic acid core with two fluorine atoms and a hydroxyl group attached to it. It is primarily used as an intermediate in the production of pharmaceuticals, agrochemicals, and various fine chemicals. 2,5-Difluoro-4-hydroxybenzoic acid is a white crystalline solid, and it is soluble in organic solvents such as ethanol and acetone. It is known for its high purity, stability, and low toxicity, making it a valuable tool in the synthesis of various compounds. 2,5-Difluoro-4-hydroxybenzoic acid is commonly used in the production of anti-inflammatory and anti-cancer drugs, as well as in the synthesis of specialized building blocks for organic synthesis.

Upstream product

• 1060739-01-6 2,5-difluoro-4-methoxybenzoic acid 
• 446-17-3 2,4,5-trifluorobenzoic acid 
• 749230-41-9 [4-chloro-3,6-difluoro-2-(methoxymethoxy)phenyl]trimethylsilane 
• 749230-38-4 [3,6-difluoro-2-(methoxymethoxy)phenyl]trimethylsilane 
• 749230-16-8 1,4-difluoro-2-(methoxymethoxy)benzene 
• 2713-31-7 2,5-difluorophenol 
• 749230-42-0 2-chloro-3,6-difluoro-4-hydroxybenzoic acid 

Downstream Products

• 1060739-01-6 2,5-difluoro-4-methoxybenzoic acid 

Relevant articles and documents

Regio-selective hydroxysubstitution of fluorobenzoic acid derivatives: Facile synthesis of fluorosalicylic acid derivatives

Ortho-substituted fluorine in 2,4-difluorobenzoic acid was found to be regio-selectively replaced to hydroxide by solid sodium hydroxide in 1,3-dimethyl-2-imidazolidinone, to afford 4-fluoro-2-hydroxybenzoic acid in high yield. Several multi-fluoro-substi

AROMATIC COMPOUND

Provided is a novel aromatic ring compound having a GPR40 agonist activity and a GLP-1 secretagogue action. A compound represented by the formula: wherein each symbol is as described in the DESCRIPTION, or a salt thereof has a GPR40 agonist activity and a GLP-1 secretagogue action, is useful for the prophylaxis or treatment of cancer, obesity, diabetes, hypertension, hyperlipidemia, cardiac failure, diabetic complications, metabolic syndrome, sarcopenia and the like, and affords superior efficacy.

The regioexhaustive functionalization of difluorophenols and trifluorophenols through organometallic intermediates

2,4-Difluorophenol, 2,5-difluorophenol, 2,3-difluorophenol, 3,5-difluorophenol, 3,4-difluorophenol, 2,4,5-trifluorophenol and 2,3,4-trifluorophenol were converted into all 18 possible di- or trifluorinated hydroxybenzoic acids (1a-c, 4a-c, 9a-c, 12a,b, 14a-c, 17a,b, 18a,b), all of them new compounds. The phenolic hydrogen atom was replaced by a methoxymethyl or, less frequently, by a triisopropylsilyl group, which exerted an ortho activating or ortho shielding effect, respectively. Sites flanked by two electronegative substituents (fluorine, alkoxy) were deprotonated with particular ease. They had to be silenced by the reversible attachment of a metalation-blocking trimethylsilyl group or of a metalation-deflecting chlorine atom if the metal was to be introduced elsewhere. In all cases but one, the stage was thus set for an intramolecular competition between metalation at an oxygen-adjacent or a fluorine-adjacent site. It proved indeed possible to secure the desired regioflexibility in either way by relying on an appropriate substrate-reagent matching. This demonstrates once more the potential of the organometallic approach to diversity-oriented synthesis.