146924-93-8 Usage
General Description
The chemical compound (3R,4S)-1-Benzoyl-3-acetoxy-4-phenyl-2-azetidinone, also known as benzoylphenylurea, is a pharmaceutical ingredient used as an anticonvulsant and anxiolytic agent. It is a chiral compound with a tetrahydro-2H-azepin-2-one core structure, and is commonly used in the synthesis of various pharmaceuticals due to its pharmacological properties. (3R,4S)-1-Benzoyl-3-acetoxy-4-phenyl-2-azetidinone is known for its ability to modulate the activity of gamma-aminobutyric acid (GABA) receptors in the central nervous system, which helps to reduce anxiety and prevent seizures. Additionally, its chemical structure also allows for its use as a building block in the synthesis of other biologically active compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 146924-93-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,9,2 and 4 respectively; the second part has 2 digits, 9 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 146924-93:
(8*1)+(7*4)+(6*6)+(5*9)+(4*2)+(3*4)+(2*9)+(1*3)=158
158 % 10 = 8
So 146924-93-8 is a valid CAS Registry Number.
InChI:InChI=1/C18H15NO4/c1-12(20)23-16-15(13-8-4-2-5-9-13)19(18(16)22)17(21)14-10-6-3-7-11-14/h2-11,15-16H,1H3/t15-,16+/m0/s1
146924-93-8Relevant articles and documents
Chemoenzymatic Synthesis of the C-13 Side Chain of Taxol: Optically Active 3-Hydroxy-4-phenyl β-Lactam Derivatives
Brieva, Rosario,Crich, Joyce Z.,Sih, Charles J.
, p. 1068 - 1075 (1993)
Enantiomerically pure 3-hydroxy-4-phenyl β-lactam derivatives have been successfully prepared via enantioselective hydrolyses and transesterifications of racemic esters and alcohols respectivily catalyzed by bacterial lipases.These lipases also catalyzed highly enantioselective cleavage of the β-lactam ring of (+/-)-10 to yield derivatives of (2R,3S)-phenylisoserine in high enantiomeric excess.The resolved enantiomers are important intermediates in the synthesis of the C-13 side chain of taxol.
