146940-54-7Relevant academic research and scientific papers
Preparation and diuretic properties of novel amiloride analogues
Russ,Ried,Ullrich,Mutschler
, p. 761 - 767 (2007/10/02)
Fifteen novel amiloride analogues were synthesized and their diuretic properties compared to amiloride and triamterene in white wistar rats. Whereas none of the 6-substituted derivatives exhibited significant natriuretic and antikaliuretic effects, five of the compounds modified in the 2-position were found equal or better than standards. The results are discussed with respect to chemical structure and physicochemical properties.
