146943-09-1

Basic information

• Product Name: N-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazine
• Synonyms: N-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazine
• CAS NO: 146943-09-1
• Molecular Weight: 353.401
• Mol File: 146943-09-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazine(146943-09-1)
• EPA Substance Registry System: N-[1-Benzo[1,3]dioxol-5-yl-meth-(E)-ylidene]-N'-[4-(4-methoxy-phenyl)-thiazol-2-yl]-hydrazine(146943-09-1)

Safety Data

• Hazardous Substances Data: 146943-09-1(Hazardous Substances Data)

Upstream product

• 5351-85-9 piperonal thiosemicarbazone 
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Relevant articles and documents

Synthesis and biological evaluation of novel 2,4-disubstituted-1,3- thiazoles as anti-Candida spp. agents

A new series of [4-(4′-substituted-phenyl)thiazol-2-yl]hydrazine derivatives were synthesized in good yield (86-99%) and characterized by elemental analysis, IR, 1H NMR, and mass spectral studies. The compounds were assayed for their in vitro broad-spectrum antifungal activity, compared to clotrimazole and fluconazole, against 20 clinical isolates of pathogenic Candida spp., representing five different species. The results showed that the presence of heterocyclic or bicyclic rings on hydrazone moiety in position C2 of thiazole revealed a promising selective inhibitory activity especially against Candida albicans and Candida glabrata.