1469439-69-7

Basic information

• Product Name: 6-fluoro-2-[4-(morpholinomethyl)phenyl]-N-(2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide
• CAS NO: 1469439-69-7
• Molecular Weight: 462.567
• Mol File: 1469439-69-7.mol

Chemical Properties

• Boiling Point: 649.5±55.0 °C(Predicted)
• Density: 1.229±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 6-fluoro-2-[4-(morpholinomethyl)phenyl]-N-(2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-2-[4-(morpholinomethyl)phenyl]-N-(2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide(1469439-69-7)
• EPA Substance Registry System: 6-fluoro-2-[4-(morpholinomethyl)phenyl]-N-(2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide(1469439-69-7)

Safety Data

• Hazardous Substances Data: 1469439-69-7(Hazardous Substances Data)

Usage

Uses

Given the provided materials, there are no explicit uses listed for 6-fluoro-2-[4-(morpholinomethyl)phenyl]-N-(2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide. However, based on its complex structure and the presence of multiple functional groups, it can be inferred that this compound may have applications in various fields such as pharmaceuticals, agrochemicals, or materials science. Here are some hypothetical uses based on its structural features:
Used in Pharmaceutical Industry:
6-fluoro-2-[4-(morpholinomethyl)phenyl]-N-(2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide could be used as a lead compound for the development of new drugs, given its complex structure and potential for pharmacological activity. The presence of the quinoline core and the morpholino group may contribute to its interaction with biological targets, such as enzymes or receptors, making it a candidate for further optimization and drug discovery efforts.
Used in Agrochemical Industry:
In the agrochemical field, 6-fluoro-2-[4-(morpholinomethyl)phenyl]-N-(2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide might be explored for its potential as a pesticide or herbicide, due to its ability to interact with specific biological targets in pests or weeds, thereby controlling their growth or causing their death.
Used in Materials Science:
6-fluoro-2-[4-(morpholinomethyl)phenyl]-N-(2-pyrrolidin-1-ylethyl)quinoline-4-carboxamide's unique structure and functional groups could also make it a candidate for use in the development of new materials with specific properties, such as in the creation of sensors, advanced polymers, or other specialized materials that require the compound's particular chemical characteristics.

Upstream product

• 7154-73-6 1-(2-aminoethyl)pyrrolidine 
• 607-40-9 6-fluoro-2-hydroxy-quinoline-4-carboxylic acid 
• 265107-94-6 1-(4-(morpholinomethyl)phenyl)ethan-1-one 
• 17201-43-3 4-cyanobenzyl bromide 
• 37812-51-4 4-(morpholin-4-ylmethyl)benzonitrile 
• 1335234-36-0 [4-(morpholinomethyl)phenyl]boronic acid hydrochloride 
• 443-69-6 5-fluoro-1H-indole-2,3-dione 

Relevant articles and documents

A novel multiple-stage antimalarial agent that inhibits protein synthesis

There is an urgent need for new drugs to treat malaria, with broad therapeutic potential and novel modes of action, to widen the scope of treatment and to overcome emerging drug resistance. Here we describe the discovery of DDD107498, a compound with a po

New derivatives of quinoline-4-carboxylic acid with antiplasmodial activity

New analogues of the recently published compound DDD107498 were prepared. Their activities were examined in vitro against the chloroquine-sensitive NF54 strain. The most active were also tested against the multiresistant K1 strain of Plasmodium falciparum. A couple of the newly synthesized compounds showed promising antiplasmodial activity and selectivity. A single compound showed adequate reduction of parasitaemia (98.1%) in mice infected with Plasmodium berghei. Survival time was doubled compared to control. The results of the biological tests of the novel compounds were compared with the activities of drugs in use. Structure-activity relationships were discussed.

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-carboxamides are described. This series was identified from a phenotypic screen against the blood stage of Plasmodium falciparum (3D7) and displayed moderate potency but with suboptimal physicochemical properties and poor microsomal stability. The screening hit (1, EC50 = 120 nM) was optimized to lead molecules with low nanomolar in vitro potency. Improvement of the pharmacokinetic profile led to several compounds showing excellent oral efficacy in the P. berghei malaria mouse model with ED90 values below 1 mg/kg when dosed orally for 4 days. The favorable potency, selectivity, DMPK properties, and efficacy coupled with a novel mechanism of action, inhibition of translation elongation factor 2 (PfEF2), led to progression of 2 (DDD107498) to preclinical development.

Anti-Malarial Agents

The present invention relates to a novel class of quinolone-4-carboxamide Pf3D7 inhibitors of general formula (I) (Formula (I)) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and in the treatment of malaria in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

ANTI-MALARIAL AGENTS

The present invention relates to a novel class of quinolone-4-carboxamide Pf3D7 inhibitors of general formula (I) (Formula (I)) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and in the treatment of malaria in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.