146953-70-0

Upstream product

• 61-90-5 L-leucine 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 37755-48-9 benzyl (2S)-2-hydroxy-4-methylpentanoate 
• 13748-90-8 (S)-2-hydroxyl-3,3-dimethylbutyric acid 

Downstream Products

• 146953-72-2 C₂₃H₃₅⁽¹⁵⁾NO₆ 
• 197172-44-4 (S)-2-(N'-tert-Butoxycarbonyl-N-{(R)-2-[(2S,3S)-2-((S)-sec-butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoyl}-hydrazino)-4-methyl-pentanoic acid benzyl ester 
• 197172-42-2 (R)-2-[(2S,3S)-2-((S)-sec-Butyl)-1-(tert-butyl-dimethyl-silanyl)-4-oxo-azetidin-3-yloxy]-4-methyl-pentanoic acid benzyl ester 

Relevant academic research and scientific papers

The development of hydrazide γ-Turn mimetics

Monte Carlo calculations show a classical γ-turn in a family of metabolites known as the malformins. This led to the synthesis of epimeric seven-membered ring γ-turn mimetics starting from leucine. NMR temperature coefficient studies were also performed.

Synthesis of (15)N-Labelled Chiral Boc-Amino Acids from Triflates: Enantiomers of Leucine and Phenylalanine

An efficient synthesis of (15)N-labelled chiral Boc-amino acids by triflate alkylation of di-tert-butyl iminodicarbonate is reported.Both enantiomers of Boc-Leucine and -phenylalanine were synthesized from commercial α-amino acids of opposite configuration via α-hydroxy carboxylic acids provided by diazotization, thus extending the scope of an earlier exploratory study.The high chiral purity of the final products was confirmed by HPLC.These labelled amino acid derivatives are suitable for direct application to the synthesis of labelled peptides.