1469778-91-3Relevant academic research and scientific papers
Synthesis of new bi(pyrazolo[1,5-a]pyrimidinyl)-7-one derivatives from dehydroacetic acid and its analogues as antibacterial agents
Aggarwal, Ranjana,Rani, Chinu,Kumar, Rajiv,Garg, Gaurav,Sharma, Jitender
, p. 120 - 134 (2014/03/21)
Synthesis of some new bi(pyrazolo[1,5-a]pyrimidinyl)-7-ones 3 was accomplished by the reaction of 3- and/or 4-substituted 5-aminopyrazoles 2 with 3-acetyl-4-hydroxy-6-methyl- 2H-pyran-2-one (dehydroacetic acid, DHAA) 1a and its analogues 1b-c in refluxing ethanol. A tentative mechanism for the formation of 3 is proposed. These compounds were evaluated for their antibacterial activity against two Gram positive bacteria i.e., Bacillus subtilis (MTCC 8509) and Bacillus stearothermophilus (MTCC 8505) and two Gram negative bacteria i.e. Escherichia coli (MTCC 119) and Pseudomonas aeruginosa (MTCC 741) using agar well diffusion assay technique and minimum inhibitory concentration (MIC) method. One of the compound 3d displayed significant antibacterial activity.
