146982-27-6

Basic information

• Product Name: FMOC-LYS(ALOC)-OH
• Synonyms: N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-EPSILON-ALLYL-OXYCARBONYL-L-LYSINE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-EPSILON-ALLYLOXYCARBONYL-L-LYSINE;N-ALPHA-FMOC-N-EPSILON-ALLYLOXYCARBONYL-L-LYSINE;N-ALPHA-FMOC-N-EPSILON-ALLOC-L-LYSINE;FMOC-LYS(ALLOC)-OH;FMOC-LYS(ALOC)-OH;FMOC-LYSINE(ALOC)-OH;FMOC-L-LYS(ALLOC)-OH
• CAS NO: 146982-27-6
• Molecular Formula: C₂₅H₂₈N₂O₆
• Molecular Weight: 452.5
• Product Categories: Amino Acids;Lysine [Lys, K];Fmoc-Amino Acids and Derivatives;peptides
• Mol File: 146982-27-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 87-91℃
• Boiling Point: 689.699 ºC at 760 mmHg
• Flash Point: 370.917 ºC
• Appearance: /Solid
• Density: 1.237 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• PKA: 3.88±0.21(Predicted)
• BRN: 5893081
• CAS DataBase Reference: FMOC-LYS(ALOC)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-LYS(ALOC)-OH(146982-27-6)
• EPA Substance Registry System: FMOC-LYS(ALOC)-OH(146982-27-6)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 146982-27-6(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C25H28N2O6/c1-2-15-32-24(30)26-14-8-7-13-22(23(28)29)27-25(31)33-16-21-19-11-5-3-9-17(19)18-10-4-6-12-20(18)21/h2-6,9-12,21-22H,1,7-8,13-16H2,(H,26,30)(H,27,31)(H,28,29)/t22-/m0/s1

Upstream product

• 105047-45-8 Fmoc-Lys-OH 
• 2937-50-0 Allyl chloroformate 
• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 147529-99-5 N^Ε-allyloxycarbonyl-L-lysine hydrochloride 

Downstream Products

• 1188000-95-4 C₅₂H₈₂N₁₀O₁₁ 
• 1188000-96-5 C₆₂H₁₀₀N₁₂O₁₅ 
• 1188000-97-6 C₇₂H₁₁₈N₁₄O₁₉ 
• 1188000-98-7 C₈₂H₁₃₆N₁₆O₂₃ 
• 1188000-99-8 C₉₂H₁₅₄N₁₈O₂₇ 
• 1188001-00-4 C₁₀₂H₁₇₂N₂₀O₃₁ 
• 1188001-01-5 C₁₁₂H₁₉₀N₂₂O₃₅ 
• 1188000-86-3 C₄₁H₆₃N₁₁O₉ 
• 1188000-92-1 C₁₀₁H₁₇₁N₂₃O₃₃ 
• 1188000-93-2 C₁₁₁H₁₈₉N₂₅O₃₇ 

Relevant articles and documents

A procedure for the large scale preparation of N(ε)-Alloc-lysine and N(ε)-Alloc-N(α)-Fmoc-lysine

This report describes a convenient procedure for a 100 g scale preparation of Fmoc-Lys(Alloc) in 85% yield. This method can be easily adapted to a near one-pot procedure with slightly reduced yields. Without requiring the isolation of the intermediate Lys(Alloc).

New effector conjugates, process for their production and their pharmaceutical use

Conjugates of epothilones and epothilone derivatives (as effectors) with suitable biomolecules (as recognition units) are described. Their production is carried out by the effectors being reacted with suitable linkers, and the compounds that are produced are conjugated to the recognition units. The pharmaceutical use of conjugates for treating proliferative or angiogenesis-associated processes is described.