1469862-48-3

Basic information

• Product Name: C₂₅H₂₅ClF₂N₄S
• Synonyms: C₂₅H₂₅ClF₂N₄S
• CAS NO: 1469862-48-3
• Molecular Weight: 487.016
• Mol File: 1469862-48-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₅ClF₂N₄S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₅ClF₂N₄S(1469862-48-3)
• EPA Substance Registry System: C₂₅H₂₅ClF₂N₄S(1469862-48-3)

Safety Data

• Hazardous Substances Data: 1469862-48-3(Hazardous Substances Data)

Upstream product

• 828-51-3 1-Adamantanecarboxylic acid 
• 711-01-3 methyl adamantane-1-carboxylate 
• 17846-15-0 adamantane-1-carbohydrazide 
• 156604-67-0 1-(1-adamantylcarbonyl)-4-(4-chlorophenyl)thiosemicarbazide 
• 877998-09-9 3-(adamantan-1-yl)-4-(4-chlorophenyl)-1H-1,2,4-triazole-5(4H)-thione 
• 50-00-0 formaldehyd 
• 5509-65-9 2,6-difluoroaniline 
• 2131-55-7 4-Chlorophenyl isothiocyanate 

Relevant articles and documents

Synthesis and antimicrobial activity of novel 5-(1-adamantyl)-2- aminomethyl-4-substituted-1,2,4-triazoline-3-thiones

The reaction of 5-(1-adamantyl)-4-substituted-1,2,4-triazoline-3-thione 5a,b and 10a,b with formaldehyde solution and various primary aromatic amines or 1-substituted piperazines yielded the corresponding N-Mannich bases 6a-o, 7a-g and 11a-i. The newly synthesized N-Mannich bases 6a-o, 7a-g and 11a-i were tested for in vitro inhibitory activities against a panel of Gram-positive and Gram-negative bacteria and the yeast-like pathogenic fungus Candida albicans. The compounds 6j, 6l, 6m, 7a, 7b, 7c, 7d, 7f, 11a, 11b, 11c, 11d, 11e, 11f, 11h and 11i displayed moderate to good activity against the tested Gram-positive bacteria, while compounds 7c, 11c, 11d, 11f and 11h showed potent broad spectrum antibacterial activity. None of the newly synthesized compounds were proved to possess marked activity against C. albicans.