1469876-08-1

Basic information

• Product Name: 9-tosyl-2-(trifluoromethyl)-9H-carbazole
• Synonyms: 9-tosyl-2-(trifluoromethyl)-9H-carbazole
• CAS NO: 1469876-08-1
• Molecular Weight: 389.398
• Mol File: 1469876-08-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 9-tosyl-2-(trifluoromethyl)-9H-carbazole(CAS DataBase Reference)
• NIST Chemistry Reference: 9-tosyl-2-(trifluoromethyl)-9H-carbazole(1469876-08-1)
• EPA Substance Registry System: 9-tosyl-2-(trifluoromethyl)-9H-carbazole(1469876-08-1)

Safety Data

• Hazardous Substances Data: 1469876-08-1(Hazardous Substances Data)

Upstream product

• 1469876-14-9 3-(trifluoromethyl)dibenzo[b,d]iodol-5-ium trifluoromethanesulfonate 
• 70-55-3 toluene-4-sulfonamide 

Relevant articles and documents

Design, synthesis and biological evaluation of: N -arylsulfonyl carbazoles as novel anticancer agents

In this work, a set of structurally diverse synthetic carbazoles was screened for their anticancer activities. According to structure-activity relationship studies, carbazoles with an N-substituted sulfonyl group exhibited better anticancer activity. Moreover, compound 8h was discovered to show the most potent anticancer effects on Capan-2 cells by inducing apoptosis and cell cycle arrest in G2/M phase. Finally, the in vivo study demonstrated that 8h prevented the tumor growth in PANC-1 and Capan-2 xenograft models without apparent toxicity.

Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity

Carbazole moiety is an important scaffold with a variety of biological applications, for example, anti-oxidative stress. Our previous synthesized carbazoles were screened for their neuroprotective properties against two individual oxidative stresses. Some of the new carbazole derivatives were observed with modest to good neuroprotective effects on neuronal cells HT22 against cell injury induced by glutamate or homocysteic acid (HCA). Substituents introduced to the carbazole ring system play crucial roles in their biological activities. In particular, a bulky group favors the neuroprotective activity of the compounds. One of the new compounds, 6, showed the best neuroprotective effects, which might result from its anti-oxidative activity with a GSH-independent mechanism. These findings might provide an alternative strategy for the development of novel carbazole derivatives for the treatment of CNS diseases such as Alzheimer's disease.