1469884-10-3

Basic information

• Product Name: C₂₂H₂₅N₇
• CAS NO: 1469884-10-3
• Molecular Weight: 387.487
• Mol File: 1469884-10-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₅N₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₅N₇(1469884-10-3)
• EPA Substance Registry System: C₂₂H₂₅N₇(1469884-10-3)

Safety Data

• Hazardous Substances Data: 1469884-10-3(Hazardous Substances Data)

Upstream product

• 1330595-61-3 3-bromo-N-(1-methylpiperidin-4-yl)imidazo[1,2-b]pyridazin-6-amine 
• 1469884-31-8 3-methyl-1-phenyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 

Relevant articles and documents

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues

The structural diversity and SAR in a series of imidazopyridazine inhibitors of Plasmodium falciparum calcium dependent protein kinase 1 (PfCDPK1) has been explored and extended. The opportunity to further improve key ADME parameters by means of lowering log D was identified, and this was achieved by replacement of a six-membered (hetero)aromatic linker with a pyrazole. A short SAR study has delivered key examples with useful in vitro activity and ADME profiles, good selectivity against a human kinase panel and improved levels of lipophilic ligand efficiency. These new analogues thus provide a credible additional route to further development of the series.