1469884-12-5

Basic information

• Product Name: C₂₁H₂₂FN₇
• Synonyms: C₂₁H₂₂FN₇
• CAS NO: 1469884-12-5
• Molecular Weight: 391.451
• Mol File: 1469884-12-5.mol

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₂FN₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₂FN₇(1469884-12-5)
• EPA Substance Registry System: C₂₁H₂₂FN₇(1469884-12-5)

Safety Data

• Hazardous Substances Data: 1469884-12-5(Hazardous Substances Data)

Upstream product

• 1469884-32-9 C₁₉H₂₅N₇O₂ 
• 1400874-20-5 N-(1-methylpiperidin-4-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-6-amine 
• 35715-66-3 1-(2-fluorophenyl)-1H-pyrazole 
• 957062-81-6 4-bromo-1-(2-fluorophenyl)-1H-pyrazole 
• 1330596-27-4 tert-butyl 4-[(3-bromoimidazo[1,2-b]pyridazin-6-yl)amino]piperidine-1-carboxylate 
• 1330595-61-3 3-bromo-N-(1-methylpiperidin-4-yl)imidazo[1,2-b]pyridazin-6-amine 
• 1402240-89-4 1-(2-fluorophenyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 
• 50-00-0 formaldehyd 

Relevant articles and documents

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues

The structural diversity and SAR in a series of imidazopyridazine inhibitors of Plasmodium falciparum calcium dependent protein kinase 1 (PfCDPK1) has been explored and extended. The opportunity to further improve key ADME parameters by means of lowering log D was identified, and this was achieved by replacement of a six-membered (hetero)aromatic linker with a pyrazole. A short SAR study has delivered key examples with useful in vitro activity and ADME profiles, good selectivity against a human kinase panel and improved levels of lipophilic ligand efficiency. These new analogues thus provide a credible additional route to further development of the series.