QL47 is a chemical compound that functions as a potent and selective inhibitor of the protein kinase CHK1, which plays a crucial role in the cell cycle checkpoint response. This involvement makes it a potential target for cancer therapy. QL47 has demonstrated its ability to inhibit the growth of various cancer cell lines, including those that are resistant to traditional chemotherapy drugs. Additionally, it has been found to enhance the cytotoxic effects of DNA-damaging agents, positioning it as a promising candidate for combination therapy. Its favorable pharmacokinetic properties and tolerability in preclinical studies further suggest its potential for further development as an anti-cancer drug.
1469988-75-7
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Basic information
- Product Name: QL47
- Synonyms: QL47
- CAS NO:1469988-75-7
- Molecular Formula: C27H21N5O2
- Molecular Weight: 447.48794
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1469988-75-7.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 706.2±60.0 °C(Predicted)
- Flash Point: N/A
- Appearance: /
- Density: 1.35±0.1 g/cm3(Predicted)
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 4?+-.0.20(Predicted)
- CAS DataBase Reference: QL47(CAS DataBase Reference)
- NIST Chemistry Reference: QL47(1469988-75-7)
- EPA Substance Registry System: QL47(1469988-75-7)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1469988-75-7(Hazardous Substances Data)
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1469988-75-7 Usage
Uses
Used in Cancer Therapy:QL47 is used as an anti-cancer agent for its ability to inhibit the growth of a variety of cancer cell lines, particularly those that have developed resistance to traditional chemotherapy drugs. Its selectivity for the protein kinase CHK1 makes it a valuable asset in targeting the cell cycle checkpoint response, a critical component in cancer cell survival and proliferation.
Used in Combination Therapy:
QL47 is used to enhance the cytotoxic effects of DNA-damaging agents, making it a promising candidate for combination therapy. This dual approach can potentially lead to more effective cancer treatments by overcoming resistance mechanisms and increasing the overall efficacy of treatment regimens.
Used in Pharmaceutical Development:
Due to its favorable pharmacokinetic properties and tolerability demonstrated in preclinical studies, QL47 is used as a candidate for further development in the pharmaceutical industry. Its potential as an anti-cancer drug makes it a valuable asset for research and development efforts aimed at improving cancer treatment options and outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 1469988-75-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,4,6,9,9,8 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.Calculate Digit Verification of CAS Registry Number 1469988-75:
(9*1)+(8*4)+(7*6)+(6*9)+(5*9)+(4*8)+(3*8)+(2*7)+(1*5)=257
257 % 10 = 7
So 1469988-75-7 is a valid CAS Registry Number.
1469988-75-7Upstream product
1469988-75-7Downstream Products
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