1469994-85-1Relevant articles and documents
Gated access to α-lithiated phenyltetrahydrofuran: Functionalisation via direct lithiation of the parent oxygen heterocycle
Mansueto, Rosmara,Mallardo, Valentina,Perna, Filippo Maria,Salomone, Antonio,Capriati, Vito
, p. 10160 - 10162 (2013/10/22)
Cycloreversion of α-lithiated phenyltetrahydrofuran was successfully tamed at -78 °C in a non-coordinating solvent in the presence of TMEDA. This anion showed excellent nucleophilicity and could be intercepted with a variety of structurally different electrophiles to give 2,2-disubstituted derivatives which can be further elaborated to γ-butyrolactones. The Royal Society of Chemistry 2013.