14700-62-0

Basic information

• Product Name: NSC46839
• Synonyms: NSC46839;2-benzyl-1H-iMidazole
• CAS NO: 14700-62-0
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.1998
• Mol File: 14700-62-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 389.5°C at 760 mmHg
• Flash Point: 214.6°C
• Appearance: /
• Density: 1.126g/cm³
• Vapor Pressure: 6.38E-06mmHg at 25°C
• Refractive Index: 1.601
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: NSC46839(CAS DataBase Reference)
• NIST Chemistry Reference: NSC46839(14700-62-0)
• EPA Substance Registry System: NSC46839(14700-62-0)

Safety Data

• Hazardous Substances Data: 14700-62-0(Hazardous Substances Data)

Usage

General Description

NSC46839 is a chemical compound that has been studied for its potential antitumor activity. It has been found to inhibit the growth of various cancer cell lines, including breast, colon, and lung cancer cells. NSC46839 has also shown anti-inflammatory and antioxidant properties, which may contribute to its potential anticancer effects. Additionally, it has been investigated for its ability to modulate immune responses and promote apoptosis in cancer cells. Further research is ongoing to better understand the mechanisms of action and potential therapeutic applications of NSC46839 in the treatment of cancer.

InChI:InChI=1/C10H10N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-7H,8H2,(H,11,12)

Upstream product

• 542-69-8 1-iodo-butane 
• 23230-39-9 1-[(dimethylamino)methyl]-imidazole 
• 140-29-4 phenylacetonitrile 
• 122-78-1 phenylacetaldehyde 
• 76100-32-8 2-Benzylimidazol-4,5-dicarbonsaeure 
• 59-98-3 tolazoline 

Downstream Products

• 84694-87-1 1-Acetyl-2-benzylimidazole 
• 1057137-21-9 2-Benzyl-1-[2-(3-nitrophenoxy)ethyl]-1H-imidazole 
• 167758-82-9 4-(2-benzyl-1H-imidazol-1-yl)benzyl alcohol 
• 162750-00-7 methyl 2-(phenylmethyl)-1H-imidazole-1-acetate 
• 122430-51-7 (4,5-dibromo-1H-imidazol-2-yl)-phenyl ketone 
• 84694-93-9 1H-5-Acetyl-2-benzylimidazole 
• 38353-02-5 2-benzoylimidazole 
• 92506-23-5 2-benzyl-1-methyl-1H-imidazole 

Relevant articles and documents

Optimisation of imidazole compounds as selective TAAR1 agonists: Discovery of RO5073012

A series of imidazole compounds has been identified which affords potent and selective partial and full agonists of the TAAR1 receptor. Starting from 2-benzyl-imidazoline screening hits, a series of structurally related 2-benzyl- and 4-benzyl-imidazoles was investigated first, but it proved highly challenging to obtain compounds having sufficient selectivity against the adrenergic alpha 2 receptor. This issue could be successfully addressed by modification of the linker region and SAR exploration led to the discovery of highly selective isopropyl-substituted 4-aminomethyl-imidazole compounds. The work culminated in the identification of the selective TAAR1 partial agonist RO5073012 (4-chlorophenyl)-(1H-imidazol-4-ylmethyl)-isopropyl-amine, 24), which has a good pharmacokinetic profile after oral administration in rodents. RO5073012 has been found to be active in a behavioural rat model which is considered indicative for schizophrenia.

An efficient preparation of 2-imidazolines and imidazoles from aldehydes with molecular iodine and (diacetoxyiodo)benzene

2-Imidazolines were easily prepared in quite good yields from the reaction of aldehydes and ethylenediamine with molecular iodine in the presence of potassium carbonate. Moreover, 2-imidazolines obtained were smoothly oxidized to the corresponding imidazoles in good yields using (diacetoxyiodo)benzene at room temperature. Georg Thieme Verlag Stuttgart.

Pyridine, pyrimidine, quinoline, quinazoline, and naphthalene urotensin-II receptor antagonists

The present invention relates to urotensin II receptor antagonists, pharmaceutical compositions containing them and their use.