147000-09-7Relevant articles and documents
Syntheses of cerulenin and its analogs. I. Cerulenin and its analogs with modified side chain
Morisaki,Funabashi,Furukawa,Shimazawa,Kanematsu,Ando,Okuda,Iwasaki
, p. 2945 - 2953 (2007/10/02)
Optically active cerulenin 1, a potent inhibitor of fatty acid synthetase, was prepared via the condensation of the epoxy aldehyde 8 and the alkenyl lithium 16. In order to evaluate the effects of (E,E)-1,4-double bonds of the cerulenin side chain on the interaction with the enzyme, a series of optically active cerulenin analogs 32a-i with modified side chains and tetrahydrocerulenin 3 were synthesized by similar procedures.