1470142-36-9Relevant articles and documents
A novel no-carrier-added submicromolar scale radiosynthesis of [S-methyl-14C]-florfenicol
Srinivas,Prabhakar,Unny,Sudhakar,Mukkanti,Choudary
, p. 382 - 384 (2013/08/23)
In this paper is reported a novel reaction scheme for the no-carrier-added submicromolar scale radiosynthesis of [S-methyl-14C]-florfenicol that has been newly designed, developed and employed by us successfully. The [ 14C]-product was obtained in an overall radiochemical yield of 30% based on [14C]-methyl iodide taken for the reaction with a radiochemical purity of more than 96%. The specific activity of the product was ~50 mCi (1.85 GBq)/mmol. Chlorosulfonation of compound I was followed by sodium salt formation in situ and it was succeeded by the introduction of [ 14C]-methyl group by coupling with [14C]-CH3I. Subsequently, the oxazolidin-2-one protecting group was opened up by a reaction with sulfuric acid in dioxane and later, the amino group was dichloroacetylated with methyl-2,2-dichloroacetate in triethylamine to obtain [S-methyl- 14C]-florfenicol. A novel method employing a newly designed reaction scheme for the no-carrier-added submicromolar scale radiosynthesis of [S-methyl-14C]-florfenicol has been developed and reported in this paper. An overall radiochemical yield of 30% based on [14C]-methyl iodide was obtained. The radiochemical purity of the final product obtained was more than 96% and specific activity was ~50 mCi (1.85 GBq)/mmol. Copyright
