1470229-66-3Relevant articles and documents
Asymmetric organocatalytic michael/henry domino reactions through hydrogen-bond activation: Kinetic access to indane scaffolds bearing cis-vicinal substituents
Loh, Charles C. J.,Atodiresei, Iuliana,Enders, Dieter
, p. 10822 - 10826 (2013)
Catalyst directs towards cis! A bifunctional hydrogen-bond-catalyzed Michael/Henry domino reaction allows preferential asymmetric access to the kinetic cis-nitroindanol products with excellent enantioselectivity through a postulated matched transition state (see scheme; H-Bo = hydrogen bond activation). This high yielding protocol opens up a new strategy to access highly useful enantio-enriched cis-aminoindanol-containing ligands and catalysts.