147023-34-5Relevant academic research and scientific papers
Total synthesis of viridiofungins A and B
Atkin, Liselle,Rizzacasa, Mark A.,Robertson, Angus,White, Jonathan M.
, p. 3557 - 3560 (2021)
The total synthesis of viridiofungins A (1) and B (2) via β-lactone 3 in 13 steps is reported. Key steps included an HF-mediated rearrangement of cyclobutene diester 9 to form a bicyclic lactone 6, an olefin cross metathesis between disubstituted alkene 3 and alkene 4 in which isomerization was suppressed, and a novel β-lactone ring opening to form the amide. Deprotection then gave either viridiofungin A (1) or B (2) in high yield.
A stereoselective synthesis of (-)-viridiofungin A utilizing a TiCl 4-promoted asymmetric multicomponent reaction
Ghosh, Arun K.,Kass, Jorden
, p. 510 - 512 (2012/03/26)
A stereoselective synthesis of (-)-viridiofungin A is described. The convergent synthesis utilized a unique highly diastereoselective multicomponent reaction between optically active phenyldihydrofuran and an α-ketoester to provide two chiral centers incl
REMEDY FOR VIRAL DISEASE
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Page/Page column 27-28, (2010/02/14)
The object of the present invention is to provide a pharmaceutical composition for preventing or treating viral infectious diseases. The compounds of the present invention have extremely potent anti-HCV activity and HCV growth inhibitory effects, and sinc
Total synthesis of viridiofungin A
Morokuma, Kenji,Takahashi, Keisuke,Ishihara, Jun,Hatakeyama, Susumi
, p. 2265 - 2267 (2007/10/03)
Viridiofungin A, a member of amino alkyl citrate antibiotics from Trichoderma viride, was enantioselectively synthesized in naturally occurring form for the first time, employing regio- and stereoselective opening of the chiral glycidate with vinylmagnesi
