147024-54-2Relevant academic research and scientific papers
Stereocontrolled synthesis of quinine and quinidine
Igarashi, Junji,Katsukawa, Masahiro,Wang, Yong-Gang,Acharya, Hukum P.,Kobayashi, Yuichi
, p. 3783 - 3786 (2007/10/03)
Disubstituted cyclopentene was prepared from cyclopentene monoacetate and transferred into disubstituted piperidine via oxidative cleavage of the olefin moiety followed by piperidine ring formation. The piperidine was then condensed at the side chain with a quinoline part to afford the olefin precursor of quinine. Finally, the olefin was converted into quinine through the corresponding epoxide. Quinidine was synthesized in a similar way.
Synthesis of a hybrid molecule containing neocarzinostatin chromophore analogue and minor groove binder
Tokuda,Fujiwara,Gomibuchi,Hirama,Uesugi,Sugiura
, p. 669 - 672 (2007/10/02)
A designed hybrid (1) of neocarzinostatin chromophore model and netropsin-type minor groove binder was synthesized and its improved ability of DNA cleavage has been demonstrated.
