Welcome to LookChem.com Sign In|Join Free

CAS

  • or

14703-80-1

Post Buying Request

14703-80-1 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

14703-80-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 14703-80-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,7,0 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 14703-80:
(7*1)+(6*4)+(5*7)+(4*0)+(3*3)+(2*8)+(1*0)=91
91 % 10 = 1
So 14703-80-1 is a valid CAS Registry Number.

14703-80-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(dimethylamino)-4-nitrophenol

1.2 Other means of identification

Product number -
Other names Phenol, 3-(dimethylamino)-4-nitro-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:14703-80-1 SDS

14703-80-1Relevant articles and documents

Novel potent BRAF inhibitors: Toward 1 nM compounds through optimization of the central phenyl ring

Ménard, Delphine,Niculescu-Duvaz, Ion,Dijkstra, Harmen P.,Niculescu-Duvaz, Dan,Suijkerbuijk, Bart M. J. M.,Zambon, Alfonso,Nourry, Arnaud,Roman, Esteban,Davies, Lawrence,Manne, Helen A.,Friedlos, Frank,Kirk, Ruth,Whittaker, Steven,Gill, Adrian,Taylor, Richard D.,Marais, Richard,Springer, Caroline J.

supporting information; experimental part, p. 3881 - 3891 (2010/02/17)

BRAF, a serine/threonine specific protein kinase that is part of the MAPK pathway and acts as a downstream effector of RAS, is a potential therapeutic target in melanoma. We have developed a series of small-molecule BRAF inhibitors based on a 1H-imidazo[4,5-b]pyridine-2(3H)-one scaffold (ring A) as the hinge binding moiety and a number of substituted phenyl rings C that interact with the allosteric binding site. The introduction of various groups on the central phenyl ring B combined with appropriate A- and C-ring modifications afford very potent compounds that inhibit V600EBRAF kinase activity in vitro and oncogenic BRAF signaling in melanoma cells. Substitution on the central phenyl ring of a 3-fluoro, a naphthyl, or a 3-thiomethyl group improves activity to yield compounds with an IC50 of 1 nM for purified V 600EBRAF and nanomolar activity in cells.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 14703-80-1