147081-44-5

Basic information

• Product Name: (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine
• Synonyms: (s)-n-boc-3-aminopyrrolidine;(S)-(-)-1-BOC-3-AMINOPYRROLIDINE;(S)-1-BOC-3-AMINOPYRROLIDINE;(S)-(-)-1-TBOC-3-AMINOPYRROLIDINE;(s)-(-)-1-tert-butoxycarbonyl-3-aminopyrrolidine;(S)-3-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(S)-3-AMINO-N-BOC-PYRROLIDINE;(S)-3-AMINO-1-TERT-BUTOXYCARBONYLPYRROLIDINE
• CAS NO: 147081-44-5
• Molecular Formula: C₉H₁₈N₂O₂
• Molecular Weight: 186.25
• EINECS: 1312995-182-4
• Product Categories: pharmacetical;chiral;Pyrrole&Pyrrolidine&Pyrroline;Benzenes;3-Aminopyrrolidines;Chiral 3-Aminopyrrolidines;Chiral Building Blocks;Heterocyclic Building Blocks;Pyrrolidines
• Mol File: 147081-44-5.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 216-217 °C(lit.)
• Flash Point: 196 °F
• Appearance: Clear colorless to yellow/Liquid
• Density: 1.067 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0146mmHg at 25°C
• Refractive Index: n20/D 1.4720(lit.)
• Storage Temp.: Room temperature.
• PKA: 9.55±0.20(Predicted)
• Sensitive: Air Sensitive
• BRN: 8312125
• CAS DataBase Reference: (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine(147081-44-5)
• EPA Substance Registry System: (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine(147081-44-5)

Safety Data

• Hazard Codes: Xn,C,Xi
• Statements: 22-41
• Safety Statements: 26
• RIDADR: UN 2810 6.1/PG 3
• WGK Germany: 2
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 147081-44-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow liqui

Uses

(S)-(-)-1-Boc-3-aminopyrrolidine may be used to prepare:Descarboxamide analog of 4-N-(Nω-nitro-L-argininyl)-trans-4-amino-L-proline amide.Histamine 3 (H3) receptor antagonists containing pyrrolidin-3-yl-N-methylbenzamide moiety.

InChI:InChI=1/C9H18N2O2/c1-9(2,3)13-8(12)11-5-4-7(10)6-11/h7H,4-6,10H2,1-3H3/t7-/m0/s1

Upstream product

• 103831-11-4 (3R)-3-aminopyrrolidine dihydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 79286-79-6 (3S)-3-aminopyrrolidine 
• 103831-11-4 (S)-3-aminopyrrolidine dihydrochloride 
• 247569-07-9 tert-butyl (S)-3-(((benzyloxy)carbonyl)amino)pyrrolidine-1-carboxylate 
• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 139986-03-1 1,1-dimethylethyl-3(R)-{[(4-methylphenyl)sulphonyl]oxy}-1-pyrrolidinecarboxylate 
• 101385-93-7 3-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 
• 202267-26-3 (S)-1-(tert-butoxycarbonyl)-3-(trifluoroacetamido)pyrrolidine 
• 127423-61-4 tert-butyl (3R)-3-methylsulfonyloxypyrrolidine-1-carboxylate 
• 125552-56-9 (S)-tert-butyl 3-azidopyrrolidine-1-carboxylate 

Downstream Products

• 362691-31-4 (S)-3-{[1-(4-cyanobenzyl)-1H-imidazol-5-ylmethyl]amino}pyrrolidine-1-carboxylic acid tert-butyl ester 
• 193267-93-5 (3S)-1-(tert-butoxycarbonyl)-3-[1-(4-nitrobenzyloxycarbonyl)-L-prolylamino]pyrrolidine 
• 427885-95-8 tert-butyl (3S)-3-[(2-nitrophenyl)sulfonylamino]pyrrolidine-1-carboxylate 
• 114636-37-2 tert-butyl (3S)-3-acetamidopyrrolidine-1-carboxylate 
• 1036488-34-2 (S)-tert-butyl 3-((4-nitrophenyl)amino)pyrrolidine-1-carboxylate 
• 1233690-46-4 (S)-tert-butyl 3-((R)-6-benzyl-2-phenethyl-2,4,5,6-tetrahydropyrazolo[4,3-e][1,4]diazepin-8(2H)-amino)pyrrolidin-1-carboxylate 
• 1345012-43-2 (S)-tert-butyl 3-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)acetamido)pyrrolidin-1-carboxylate 
• 1345012-44-3 (S)-tert-butyl 3-(2-((4-methoxybenzyl)(pyridin-2-yl)amino)ethylamino)pyrrolidin-1-carboxylate 
• 193269-79-3 tert-butyl (3S)-3-(2-aminoacetylamino)-1-pyrrolidinecarboxylate 
• 1352660-22-0 C₁₇H₂₃N₃O₆ 
• 1352660-62-8 C₁₆H₂₂N₂O₄ 
• 1352660-47-9 C₂₆H₃₀N₆O₁₀ 
• 1245318-58-4 5-amino-2-[2-(4-fluorophenyl)ethyl]-7-(1-tert-butoxycarbonylpyrrolidin-3-(S)-ylamino)-thiazolo[5,4-d]pyrimidine 
• 1245318-61-9 5-amino-2-[2-(4-fluorophenyl)ethyl]-7-(1-(4-chlorophenoxyacetyl)pyrrolidin-3-(S)-ylamino)-thiazolo[5,4-d]pyrimidine 

Relevant articles and documents

The identification and use of robust transaminases from a domestic drain metagenome

Transaminases remain one of the most promising biocatalysts for use in chiral amine synthesis, however their industrial implementation has been hampered by their general instability towards, for example, high amine donor concentrations and organic solvent content. Herein we describe the identification, cloning and screening of 29 novel transaminases from a household drain metagenome. The most promising enzymes were fully characterised and the effects of pH, temperature, amine donor concentration and co-solvent determined. Several enzymes demonstrated good substrate tolerance as well as an unprecedented robustness for a wild-type transaminase. One enzyme in particular readily accepted IPA as an amine donor giving the same conversion with 2-50 equivalents, as well as being tolerant to a number of co-solvents, and operational in up to 50% DMSO-a characteristic as yet unobserved in a wild-type transaminase. This work highlights the value of using metagenomics for biocatalyst discovery from niche environments, and here has led to the identification of one of the most robust native transaminases described to date, with respect to IPA and DMSO tolerance.

Aromatic heterocyclic derivatives and applications of aromatic heterocyclic derivatives in medicines

The present invention discloses aromatic heterocyclic derivatives and applications of the aromatic heterocyclic derivatives in medicines, and specifically provides a class of aromatic heterocyclic compounds or stereoisomers, geometric isomers, tautomers, racemic bodies, nitrogen oxides, hydrates, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, and pharmaceutical compositions containing the compounds. The present invention further discloses uses of the compounds or pharmaceutical compositions in drug preparation, wherein the drug is used for treatment of respiratory diseases, particularly chronic obstructive pulmonary disease (COPD).

Connecting Unexplored Protein Crystal Structures to Enzymatic Function

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