147082-06-2

Upstream product

• 23912-28-9 (2S,4S)-4-(4-methoxybenzylthio)-2-pyrrolidinecarboxylic acid 
• 4457-32-3 4-nitrobenzyl chloroformate 

Downstream Products

• 162215-24-9 (2S,4S)-2-hydroxymethyl-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 138507-90-1 (2S,4S)-2-[4-(2-Hydroxyethyl)-1-piperazinylcarbonyl]-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxy-carbonyl)pyrrolidine 
• 147081-41-2 (2S,4S)-4-(4-methoxybenzylthio)-2-[(S)-3-(4-nitrobenzyloxycarbonylamino)pyrrolidin-1-ylcarbonyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 147081-48-9 (2S,4S)-2-[(3S)-3-dimethylamino-1-pyrrolidinylcarbonyl]-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 153836-53-4 (2S,4S)-4-(4-methoxybenzylthio)-2-[(S)-1-methyl-3-pyrrolidinylaminocarbonyl]-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 
• 153836-26-1 (2S,4S)-2-(3-aminoazetidin-1-ylcarbonyl)-4-(4-methoxybenzylthio)-1-(4-nitrobenzyloxycarbonyl)pyrrolidine 

Relevant academic research and scientific papers

CARBEPENEM DERIVATIVES

Carbapenem derivatives which may be utilized as antibiotics and which show strong antibacterial activity against various bacterial strains including Pseudomonas aeruginosa. The compounds containing the derivatives are quite safe and are also stable against hydrolases such as dehyropeptidase (DHP)

Carbapenem derivatives having antibiotic activity, their preparation and their use

Carbapenem compounds of formula (I): STR1 in which: A is a fully saturated heterocyclic group, of which at least one ring atom is nitrogen; R1 is hydrogen or methyl; R2 is hydrogen or alkyl; R3 is hydrogen or a negative io