147088-71-9

Usage

Uses

Used in Dye and Pigment Manufacturing:
Phthalazine-5,8-dione is utilized as a key intermediate in the production of dyes and pigments, contributing to the development of vibrant and stable colorants for various applications.
Used in Pharmaceutical Industry:
Phthalazine-5,8-dione serves as an essential component in the synthesis of pharmaceuticals, playing a crucial role in drug development and the creation of new therapeutic agents.
Used in Organic Synthesis:
As an intermediate in organic synthesis, Phthalazine-5,8-dione is used for the preparation of a wide range of organic compounds, showcasing its versatility in chemical reactions.
Used in Research Laboratories:
Phthalazine-5,8-dione is employed in research settings for conducting chemical reactions and experiments, further exploring its potential applications and properties.
Used in Medicinal Chemistry:
Due to its unique chemical structure, Phthalazine-5,8-dione has potential uses in medicinal chemistry, where it may contribute to the discovery and development of novel drugs and therapeutic agents.

Upstream product

• 253-52-1 PHTHALAZINE 
• 89898-86-2 5-nitrophthalazine 
• 102072-84-4 5-aminophthalazine 

Downstream Products

• 102072-85-5 DA 3044 

Relevant academic research and scientific papers

Ezrin inhibitors and methods of making and using

The invention encompasses compound and pharmaceutical composition comprising the compound of the following Formula (I): or pharmaceutically acceptable salts or prodrugs thereof, that are useful for inhibiting ezrin protein in a cell or for inhibiting the growth of a cancer cell.

Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma

Respiratory failure due to pulmonary metastasis is the major cause of death for patients with osteosarcoma. However, the molecular basis for metastasis of osteosarcoma is poorly understood. Recently, ezrin, a member of the ERM family of proteins, has been associated with osteosarcoma metastasis to the lungs. The small molecule NSC 668394 was identified to bind to ezrin, inhibit in vitro and in vivo cell migration, invasion, and metastatic colony survival. Reported herein are the design and synthesis of analogues of NSC 668394, and subsequent functional ezrin inhibition studies. The binding affinity was characterized by surface plasmon resonance technique. Cell migration and invasion activity was determined by electrical cell impedance methodology. Optimization of a series of heterocyclic-dione analogues led to the discovery of compounds 21k and 21m as potential novel antimetastatic agents.

Synthesis and antifungal activity of 6-arylamino-phthalazine-5,8-diones and 6,7-bis(arylthio)-phthalazine-5,8-diones

6-Arylamino-phthalazine-5,8-diones and 6,7-bis(arylthio)-phthalazine-5,8-diones were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Among those tested, many compounds showed good antifungal activity. The results suggest that phthalazine-5,8-diones would be potent antifungal agents.

Studies of Phthalazine-5,8-quinone, A Ring Contraction, and Some Novel and Potentially Useful Fluorescent Phthalimides

Phthalazine-5,8-quinone 3 has been obtained and some derivatives prepared.Treatment of 5,8-dimethoxy 14 and 5-hydroxy-8-methoxy-2,3-dihydrophthalazin-1,4-dione 16 with ceric ammonium nitrate produces an efficient ring contraction reaction to yield the hig