147092-44-2

Basic information

• Product Name: 5-hydroxy-2-phenyl-2-(2-pyridyl)pentanenitrile
• Synonyms: 5-hydroxy-2-phenyl-2-(2-pyridyl)pentanenitrile
• CAS NO: 147092-44-2
• Molecular Weight: 252.316
• Mol File: 147092-44-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-hydroxy-2-phenyl-2-(2-pyridyl)pentanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-hydroxy-2-phenyl-2-(2-pyridyl)pentanenitrile(147092-44-2)
• EPA Substance Registry System: 5-hydroxy-2-phenyl-2-(2-pyridyl)pentanenitrile(147092-44-2)

Safety Data

• Hazardous Substances Data: 147092-44-2(Hazardous Substances Data)

Upstream product

• 5005-36-7 phenyl-pyridin-2-yl-acetonitrile 
• 627-30-5 1-chloro-3-hydroxypropane 
• 67-68-5 dimethyl sulfoxide 

Relevant articles and documents

Reaction of 4-(N,N-dimethylamino)-2-phenyl-2-(2-pyridyl)butanenitrile and related compounds with ethyl chloroformate; formation of indolizinium and quinolizinium chlorides

4-(N,N-Dialkylamino)-2-phenyl-2-(2-pyridyl)butanenitriles (10, 11 and 12) and 5-(N,N-dimethylamino)-2-phenyl-2-(2-pyridyl)pentanenitrile (13) react with ethyl chloroformate, via a cyclization-N-dealkylation process, to give indolizinium and quinolizinium salts (1 and 2). Compounds 1 and 2 are also obtained by reaction of the alcohol derivatives 14 and 15 with thionyl chloride. Reaction of 2-phenyl-2-(2-pyridyl)ethanenitrile (9) in the presence of potassium hydroxide in dimethyl sulfoxide, leading to [2-hydroxy-2-phenyl-2-(2-pyridyl)ethyl]methylsulfoxide (21), is also described.