147097-80-1

Upstream product

• 6940-57-4 2-acetyl-6-methylpyridine 

Downstream Products

• 1418306-02-1 2-(2-(benzylsulfonyl)-1H-imidazol-4-yl)-6-methylpyridine 
• 1418306-05-4 2-(2-(benzylsulfonyl)-4-(6-methylpyridin-2-yl)-1H-imidazol-1-yl)ethanol 
• 1418306-00-9 N-[5-(6-methyl-pyridin-2-yl)-1H-imidazol-2-yl]-acetamide 
• 1418306-03-2 2-(2-(benzylthio)-1H-imidazol-4-yl)-6-methylpyridine 

Relevant academic research and scientific papers

TGF BETA RECEPTOR ANTAGONISTS

The invention relates generally to compounds of formula (I) that modulate the activity of TGFβR-l and TGFβR-2, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK5 AND/OR ALK4 INHIBITORS

The present invention provides a novel 2-pyridyl substituted imidazole derivative, or a pharmaceutically acceptable salt or solvate thereof, which selectively inhibits the transforming growth factor-β (TGF-β) type I receptor (ALK5) and/or the activin type