1471-86-9

Basic information

• Product Name: ethyl 4-methyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylate
• CAS NO: 1471-86-9
• Molecular Formula: C₁₁H₁₁N₃O₃
• Molecular Weight: 233.2233
• Mol File: 1471-86-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 388.1°C at 760 mmHg
• Flash Point: 188.5°C
• Density: 1.35g/cm³
• Vapor Pressure: 3.14E-06mmHg at 25°C
• Refractive Index: 1.625
• CAS DataBase Reference: ethyl 4-methyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-methyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylate(1471-86-9)
• EPA Substance Registry System: ethyl 4-methyl-3-oxo-3,4-dihydropyrido[2,3-b]pyrazine-2-carboxylate(1471-86-9)

Safety Data

• Hazardous Substances Data: 1471-86-9(Hazardous Substances Data)

Upstream product

• 5028-20-6 3-amino-2-methylaminopyridine 
• 609-09-6 Diethyl ketomalonate 

Downstream Products

• 1471-85-8 4-Methyl-3-oxo-1,2,3,4-tetrahydro-pyrido[2,3-b]pyrazine-2-carboxylic acid ethyl ester 
• 187098-38-0 7-Benzyl-10-methyl-6,7-dihydro-10H-1,4b,7,10-tetraaza-phenanthrene-5,8,9-trione 

Relevant articles and documents

Synthesis of 1H-pyrazino[1,2-a]pyrido[2,3-e]pyrazine and 2H-pyrano[2,3-b]pyrido[2,3-e]pyrazine derivatives

With a continuing interest on heteropolycyclic structures which may show biological activities, we synthesized new tricyclic derivatives in which the pyridopyrazine skeleton is fused with pyrazine 7 and 8, B, n = 1. However, the initial design of obtaining also the cyclohomologous structure B (n = 2) produced instead a pyranopyridopyrazine derivative 11. Thus during the attempt to prepare a pyridodiazepine intermediate, beside a very small amount of the desired product 10, the pyridopyrazine 9 was obtained. The latter compound reacted with chloroacetyl chloride/chloroketene to give 4-carbethoxy-10-(chloroacetyl)-5,10-dihydro-5-methyl-2H-pyrano[2,3-b]p yrido[2,3-e]pyrazin-2-one (11). In studying the behavior of this derivative, compounds 12-14 were obtained. Compounds 4b,c, 5a,b, 7, 8, 9 and 14 have been submitted to preliminary pharmacological screening as CNS depressant agents.