147108-60-9Relevant academic research and scientific papers
Syntheses of 4-amino-, 4-hydroxy-, and 4-nitro-1,3,4,5-tetrahydrobenz[cd]indoles and its bromination
Nakagawa, Kyoko,Aoki, Naokatsu,Mukaiyama, Harunobu,Somei, Masanori
, p. 493 - 520 (2014)
Simple synthetic method for 4-nitro-1,3,4,5-tetrahydrobenz[cd]indole (6) is established from indole-3-carboxaldehyde (7). With 6 in hand, various derivatives of 4-amino-, 4-hydroxy- and 4-amino-4-hydroxymethyl-1,3,4,5-tetrahydrobenz[cd]indoles become readily available. Bromination of 6 afforded useful building blocks for further manipulation. Successful optical resolution of 6 by chiral column chromatography is also reported.
A SIMPLE FOUR STEP SYNTHESIS AND OPTICAL RESOLUTION OF 4-NITRO-1,3,4,5-TETRAHYDROBENZINDOLE, AND THE SYNTHESES OF 1-HYDROXY DERIVATIVES OF 4-NITRO- AND 4-AMINO-1,3,4,5-TETRAHYDROBENZINDOLES
Nakagawa, Kyoko,Aoki, Naokatsu,Mukaiyama, Harunobu,Somei, Masanori
, p. 2269 - 2275 (2007/10/02)
4-Nitro-1,3,4,5-tetrahydrobenzindole was synthesized from indole-3-carboxaldehyde in four steps with an overall yield of 30percent.Optical resolution of its enantiomers by chiral column chromatography was successful.Syntheses of 1-hydroxy derivatives of 4-nitro- and 4-amino-1,3,4,5-tetrahydrobenzindoles are also reported.
